PhD Students ,Max-Planck-Institute for Molecular Biomedicine,Germany

The Max-Planck-Institute for Molecular Biomedicine and the Center for Molecular Biology of Inflammation has openings for several

PhD Students

(position-code 04-2011)

to investigate the cellular mechanisms regulating blood vessel formation (Dr. Arndt Siekmann, MPI) in developing zebrafish.

The group of Dr. Arndt Siekmann studies the signaling pathways important during endothelial cell differentiation and angiogenic growth of the vasculature. An additional interest lies in the guidance cues that play a role in endothelial cell migration. Possible projects involve studying blood vessel formation during regeneration of the zebrafish fins and the analysis of genes regulated by changes in blood flow. Technical approaches include genetic studies, involving the use of zinc finger nucleases to introduce mutagenic lesions, confocal and time-lapse microscopy, immunohistochemistry, cell transplantation studies, molecular biology and bioinformatics.

For further information please visit the Siekmann lab website:
http://www.mpi-muenster.mpg.de/research/teams/groups/rgsiekmann/index.html
We invite applications by enthusiastic, committed and highly talented PhD students who wish to join my laboratory. Stipends are provided for up to three years. The institutes offer a very international environment with English being the language spoken in the laboratories. Please include a letter of motivation (up to one page) describing why you would like to pursue a PhD in my laboratory with your application. Only applications containing such a letter of motivation will be considered.

The Max-Planck-Society is committed to employing more handicapped individuals and especially encourages them to apply. The Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

Please send your application (with the position-code 04-2011), letter of motivation and CV and the names of 2 referees via email to:
career@mpi-muenster.mpg.de
Max Planck Institute for Molecular Biomedicine
Roentgenstrasse 20
48149 Muenster
Germany

PhD "Inflammation Research" Molecular Pharmacology,Grünenthal GmbH,Aachen,Germany

Grunenthal GmbH, Global Preclinical R&D, Molecular Pharmacology, seeks candidates for the following position: an experienced PhD candidate with a background in “Inflammation Research”

Required:

PhD “Inflammation Research” in Molecular Pharmacology:
We are looking for a highly motivated scientist (PhD or MD) with a strong background in inflammation research including an in-depth understanding of the pathology of chronic inflammatory diseases and the respective molecular pathways. The candidate should have a minimum of 3 years of working experience and track record of interdisciplinary research preferably in a pharma/biotech industry or academic setting. A profound knowledge of immune cell function and signalling pathways is required. Additional knowledge on biotherapeutics is regarded as a surplus. The candidate will contribute to the target identification, evaluation and validation in the area of chronic inflammation and autoimmune diseases, resulting in novel projects for drug discovery (assay development, screening, lead finding and optimization). This includes the establishment and management of internal resources as well as external (international) collaborations with CROs and academic groups. The candidate will closely interact with members of other research disciplines with the goal to advance research projects from an exploratory to a proof-of-concept status. 

 
We expect a highly self-motivated and well organized person with initiative and creativity as well as social competence. You should be a team player with good networking skills. Excellent communication and presentation skills including fluency in English language are mandatory.

Please send a letter of application, CV, and copies of university degrees/marks to :

Rita Hugo-Olbertz, Global Human Resources, 52099 Aachen or Rita.Hugo-Olbertz@grunenthal.com

Doctoral Students, Post-Doc Fellows and Junior Scientists,Max Planck Institute for Demographic Research,Germany

The Max Planck Institute for Demographic Research seeks several doctoral students, post-doc fellows and junior scientists interested in statistical analysis and mathematical modeling to collaborate with biologists, demographers and statisticians on path-breaking research on the RATE OF AGEING in humans and across the tree of life. Applications will be reviewed as received, with research starting February to October 2011.
For details see http://www.demogr.mpg.de/go/appl-rate-of-aging

Postdoc in Biomicrofluidics,Technische Universität Darmstadt, Germany

A full-time position for a post-doctoral fellow is available in the laboratory of Dr. Robert Stark (Center of Smart Interfaces and Dept. of Materials Science, Technical University of Darmstadt, Germany).

Microfluidic systems with functional surfaces are valuable tools for biomedical research. Highly specialized devices allow us to investigate various biological processes in vitro. Our aim is to develop polymer microdevices for biomicrofluidic applications with tailored surface properties to optimize the functionality.

The successful candidate has graduated with a PhD within the past three years in materials sciences, engineering, physics or a related discipline. Applicants with a strong background in microdevice fabrication and microfluidics are encouraged to apply. Fluent English and proven writing skills together with a strong interest for biological systems allow the candidate to communicate with partners in biology or medicine.
The position (TVL-E13) is fully funded and available immediately. The initial appointment will be for one year with the potential for extension depending upon performance.

TU Darmstadt is committed to equal opportunity in employment and gender equality in its working environment. To increase equal gender distribution, we strongly encourage applications from qualified women. Preference will be given to applicants with disabilities who are equally qualified.
Please e-mail your application (CV, list of publications, letter of motivation and contact details of two referees) to

Prof. Dr. Robert Stark, Center of Smart Interfaces, Physics of Surfaces, TU Darmstadt, Petersenstr. 32, 64287 Darmstadt, Germany. Email: stark@csi.tu-darmstadt.de

PhD Position in Behavioral Neurogenetics,University Cologne,Germany

A PhD position is available at the Institute of Animal Physiology at the University of Cologne (Köln), Germany. The work of our group aims to identify genes and mechanism underlying alcoholism. Towards this end we are using the genetic model organism Drosophila melanogaster that shares behavioral and mechanistic similarities to humans. The project focuses on the molecular bases of ethanol induced behavior and the analysis of neurons mediating this behavior. For our studies we are using a combination of genetic, molecular genetic, neuroanatomical and behavioral approaches.

Applicants should have a strong interest in neurobiology and behavior. Experiences in Drosophila genetics, molecular genetics and image analysis techniques including confocal microscopy would be desirable. We are seeking a highly motivated and interested person to join our research group. We provide an interesting and challenging research environment. The position will be financed by a stipend of the Graduate School of Biological Science and is available immediately. 

Deadline of the application is the 25th of February 2011.
Please send your application including a cover letter, a CV, name and addresses of two references, and a certification of the academic qualification, preferentially electronically to:
henrike.scholz@uni-koeln.de

Department of Animal Physiology
Zuelpicher Strasse 47b
50674 COLOGNE, Germany
http://WWW.NEURO.UNI-KOELN.DE

PhD Student in Plant Innate Immunity,ZMBP, University of Tuebingen, Germany

The Center for Plant Molecular Biology ZMBP in Tübingen/Germany invites biologists or biochemists to apply for a PhD student position jointly supervised by renowned Distinguished Guest Professor Jeffrey Dangl *(University of North Carolina, Chapel Hill). This position *(E13 TV-L / 50%) is now available for three years. The major topic of the work will be the molecular, mechanistic and physiological analysis of receptor kinases implicated in plant immunity to microbial infection. Particular emphasis will be put on those receptors that are target of interference by microbial effectors. For more information on our labs please visit http://www.mnf.uni-tuebingen.de/fachbereiche/zentren/zmbp/plant-biochemistry.html or http://www.bio.unc.edu/faculty/dangl/. For more information on the project please contact us via email: birgit.kemmerling@zmbp.uni-tuebingen.de.

We offer an innovative and scientifically stimulating environment, a well-equipped lab as well as an international and cooperative research team. The highly motivated candidate must hold an excellent degree in biology or biochemistry, should be fluent in English and should have some experience in protein biochemistry and/or molecular biology. Please send as soon as possible a cover letter, a CV and names of 

two references preferably by email to:

Prof. Dr, Thorsten Nürnberger/Dr. Birgit Kemmerling
ZMBP – Plant Biochemistry
University Tuebingen
Auf der Morgenstelle 5
72076 Tuebingen/Germany
e-mail: nuernberger@zmbp.uni-tuebingen.de
e-mail: birgit.kemmerling@zmbp.uni-tuebingen.de
phone:             +49-(0)7071-29-76654      

PhD-small GTPases in cancer,Turku Centre for Biotechnology,Finland

1 PhD student position
in structure-function studies of small GTPases in cancer

in the Mechanism and Biosensors of small GTPases Group of Daniel Abankwa at the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku Finland (www.btk.fi). Turku is a beautiful old city located in south-western corner of Finland surrounded by a magnificent archipelago with thousands of small islands (http://www.saaristo.org/eng/).

Our research focuses on the membrane organization and signaling activity of small GTPases of the Ras-, Rho- and Rab-family. We have recently described a novel switch III region for Ras proteins, which is associated with formerly unappreciated conformers of membrane bound Ras. This mechanism profoundly influences Ras biology (Abankwa D et al. (2008) Embo J 27(5): 727-735; Abankwa D et al. (2010) PNAS 107(3): 1130-1135). We will be using cutting-edge cellular imaging (Fluorescence Lifetime Imaging Microscopy, FLIM, and STED-nanoscopy), high-throughput approaches (high-content and cytometer chemical- and RNAi-screening) and animal models to answer exciting questions around this newly discovered mechanism.

The Centre for Biotechnology offers state-of-the-art research facilities for bioimaging, proteomics, genomics, crystallography, which support excellence in research in the greater Turku area. The Cell Imaging Core features very good equipment for life-cell imaging, high-content and confocal microscopy, as well as state of the art FACS service and high-throughput flow cytometry. In particular, it serves as the Nordic reference site for the Leica STimulated Emission Depletion (STED)-superresolution microscope.

We are looking for candidates with top academic qualifications and high self-motivation, who recently earned their masters degree in a discipline related to biophysics. Practical experience with two of the following skills is a requirement: protein purification, quantitative fluorescence imaging, cellular transformation assays, FRET/FLIM, FCS or related spectroscopic methods. Practical experience with molecular biology techniques (cloning, PCR etc.) is desirable.

The stipend 1400 €/month net (not taxable) is commensurate with typical university salary scales for graduate students.

Please send preferably as one merged pdf: a short CV that highlights your most outstanding achievements, as well as the email contacts of 2-3 referees (these may also be course advisors) and a brief description of your specific motivation to join the group (approx. 1/2 A4 page) to daniel.abankwaATbtk.fi with the subject line ‘research candidate’. The positions should commence early 2011. Applications are open from January 2011 until the positions are filled.

PhD Students in Molecular Medicine,Institute for Molecular Medicine Finland FIMM, Helsinki, Finland

The Institute for Molecular Medicine Finland (FIMM, www.fimm.fi ) was established in 2007 as a partner institution of the European Molecular Biology Laboratory ( www.embl.org ) together with Nordic nodes for molecular medicine in Norway (NCMM) and Sweden (MIMS). FIMM is a joint venture of the University of Helsinki, the Hospital District of Helsinki and Uusimaa (HUS), the National Institute for Health and Welfare (THL) and the VTT Technical Research Centre of Finland. FIMM laboratories are located in a brand new state-of-the-art Biomedicum Helsinki 2 research building on the Meilahti medical campus in Helsinki.
FIMM is currently seeking outstanding candidates for positions of

PhD Students in Molecular Medicine
starting in August 2011.


Description: FIMM is a multi-disciplinary research institute combining high-quality science with state-of-the-art technologies with the goal of building a bridge from biomedical research and discovery to medical applications. FIMM works together with the Helsinki Biomedical Graduate School (HBGS) and other graduate area programs to provide excellent research training and courses aiming at a PhD degree at the University of Helsinki. As part of a joint call of the Nordic EMBL Partnership for Molecular Medicine, we currently have openings for PhD students who show outstanding potential to become independent researchers and who will significantly benefit from the institute’s four-year program.

Qualification and experience: Candidates should have a relevant academic degree (MSc, MD or equivalent) in biology, biochemistry, biotechnology, genetics, medicine, information science or other related fields, obtained before the starting date. The successful candidate is expected to have good problem solving, troubleshooting, and analytical skills. In addition, the candidate should be fluent in English, have good interpersonal and written and oral communication skills, and be able to work independently as well as within an international team. A demonstrated interest in molecular medicine is also advantageous.

Application and selection process: Application should be written in English and include a cover letter, CV or resume, and a one-page statement of motivation and research interests that describes specifically how the candidate would integrate into the FIMM research groups. The application package should demonstrate that the applicant has potential to become an independent researcher and will significantly benefit from the institute’s four-year program. Applications should be submitted as a single .pdf file online at http://www.fimm.fi/en/open_positions/ no later than February 15, 2011, at 15.45. No applications submitted after the deadline will be accepted.

The top candidates will be invited for an interview with an international search committee. The selected candidates will be offered an initial contract for one year during which time students will engage in diverse training through research group rotations. The intial contract will be extended for an additional three-year period upon successful review.

For further information please visit our website www.fimm.fi or contact Gretchen Repasky, Coordinator of Research Training (gretchen.repasky@fimm.fi). Further information about Helsinki Biomedical Graduate Program: www.hbgs.helsinki.fi and University of Helsinki International Staff Services: www.helsinki.fi/intstaff/.
Research Areas and Principal Investigators of FIMM

The research areas of FIMM include:
- Human genomics
- Medical systems biology and bioinformatics of common diseases, with a focus on cancer, diabetes and obesity
- Translational research, including health impact of genes, new diagnostic methods, biomarkers and therapeutics.

In addition to the research areas at FIMM, the FIMM Technology Centre develops state-of-the-art infrastructures for genomics, medical bioinformatics, high-throughput chemical and siRNA screening, biobanking, biomarker discovery and other translational research platforms.

The group leaders of FIMM include:
Human Genomics: Samuli Ripatti, Juni Palmgren, Aarno Palotie, Janna Saarela, Elisabeth Widén
Medical Systems Biology:Denis Kainov, Olli Kallioniemi, Sergey Kuznetsov, Emmy Verschuren, Krister Wennerberg
Translational Research:Jonathan K.C. Knowles, Johan Lundin
FIMM is linked with two Centres of Excellence of the Academy of Finland:
- CoE in Complex Disease Genetics (www.ktl.fi/diseasegenetics/) and
- CoE in Translational Genome-Scale Biology (tgsb.vtt.fi) as well as with the
The FIMM National Network for Molecular Medicine consists of prominent scientists, who have an adjunct affiliation with FIMM and carry out collaborative research projects with FIMM. (http://www.fimm.fi/en/research/nationalnetwork/).
Helsinki 19 January 2011
Institute for Molecular Medicine Finland (FIMM)

PhD fellowships in pharmaceutical sciences,University of Copenhagen,Denmark

The Faculty of Pharmaceutical Sciences, University of Copenhagen is pleased to announce that six PhD fellowships will be available from 1 April 2011 or as soon as possible thereafter. Applications are invited for the three-year fellowship from candidates that hold or expect to hold a master’s degree in a field relevant to the following projects:

1. MEDICINAL CHEMISTRY
Design and synthesis of epigenetic-drugs. Supervisors: Associate Professors Rasmus Prætorius Clausen and Jesper Kristensen, Department of Medicinal Chemistry (emails: rac@farma.ku.dk and jekr@farma.ku.dk).
The project is co-financed by the Danish Cancer Society and the Faculty of Pharmaceutical Sciences and is affiliated to the research training programme, Drug Research Academy (mobility fellowship).

2. DRUG DELIVERY
Intestinal and renal transport mechanism of vigabatrin: A mechanism-based approach to identify drug interactions. Main supervisor: Associate Professor Carsten Uhd Nielsen, Department of Pharmaceutics and Analytical Chemistry, phone +45 3533 6472 (email: cun@farma.ku.dk).

3. METABOLIC SYNDROME/DRUG DELIVERY
Absorption of 2-oleoyl glyceryl ether in intestinal cells. Main supervisor: Professor Harald S. Hansen, Department of Pharmacology and Pharmacotherapy, phone +45 3533 6332 (email: hsh@farma.ku.dk).

4. OPTIMAL DRUG THERAPY
Long term use of nicotine replacement therapy (NRT). Main supervisor: Professor Lona L. Christrup, Department of Pharmacology and Pharmacotherapy, phone +45 3533 6347 (email: llc@farma.ku.dk).
The applicant for this project must speak Danish fluently.

5. MEDICINAL CHEMISTRY
Antibacterial peptides as novel delivery vehicles for genetic antibiotics. Main supervisor: Associate Professor Henrik Franzyk, Department of Medicinal Chemistry, phone +45 3533 6255 (email: hf@farma.ku.dk).

6. DRUG DELIVERY
A mechanistic approach to optimize membrane interaction of antimicrobial peptides. Main supervisor: Associate Professor Hanne Mørck Nielsen, Department of Pharmaceutics and Analytical Chemistry, phone +45 3533 6346 (email: hmn@farma.ku.dk).
The project is co-financed by DANCARD and the Faculty of Pharmaceutical Sciences.

The PhD fellowships are to be completed in accordance with the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Technology and Innovation and the Regulations and guidelines for the conferment of the PhD degree by the Faculty of Pharmaceutical Sciences. The terms of employment are stated in the agreement between The Danish Confederation of Professional Associations and the Ministry of Finance.

As an equal opportunity employer, the Faculty of Pharmaceutical Sciences invites applications from all interested candidates regardless of gender, age, ethnic origin or religion.

For further information, applicants may contact the main supervisor.

How to apply
STEP ONE: Make one pdf-file (max 10 mb) with the following contents:

   1. Letter stating the interest and qualifications for the project (max. one page)
      C # V
   2. Master’s degree diploma (including grade transcripts for bachelor’s and master’s degrees)
   3. Possible publication list
   4. Possible references
   5. Applicants with a Master’s degree from abroad should also enclose a short description of the grading scale used.

STEP TWO: Fill in the application form and upload the pdf. The application form is linked from the announcement: www.farma.ku.dk/stillinger

STEP THREE: Print the pdf-file and send one hard copy in an envelope marked “Reference 211-0055/11-0900” to:

University of Copenhagen
Faculty of Pharmaceutical Sciences
Universitetsparken 2
DK – 2100 Copenhagen
Denmark

The hard copy has to be received at the Faculty of Pharmaceutical Sciences before the application deadline.

Deadline for applications: Friday 11 February 2011 at 12 o’clock noon.

An answer as to the granting of the fellowships can be expected appr. 5-6 weeks after application deadline.

Phd in nanoscience and nanotechnology, Adam Mickiewicz University,Poland

RECRUITMENT PROCEDURES FOR PHD PROGRAM IN NANOSCIENCE ANDNANOTECHNOLOGY 

PHYSICS FACULTY – NANOBIOMEDICAL CENTRE AT ADAM MICKIEWICZUNIVERSITY IN POZNAN

ADMISSION REQUIREMENTS

A master’s degree – or M.Sc. equivalent – in science (e.g. physics, biology, chemistry, medicine, biophysics) or engineering field, obtained not earlier than in 2005, is required for admission in the PhD Program.
1. Diploma must be graded at least good (or equivalent).
2. Fluent knowledge of English.

DOCUMENTS TO BE SUBMITTED
1. Official transcripts of an M. Sc. Diploma together with a detailed list of all courses taken.
2. Final diploma in attended faculty, obtained not earlier than in 2005.
3. Two letters of recommendation, written by individuals (i.e. Tutor/ Referee). Letters should point the applicant’s suitability for a PhD program.
4. A letter of intent (maximum two A4 pages) that presents previous research achievements, participation in conferences and seminars, publications, professional goals and motivation for joining “The PhD program in Nanoscience and Nanotechnology”, suitability for the program, and career goals.
5. Optionally: certificates confirming advanced knowledge in English (e.g. CAE or TOEFL).
6. Application form.
The documents must be submitted by post. Hard copies of all official documents should be supplied by the interview day.

DEADLINES:
Submission of application form: 01.03.2011
Interviews for shortlisted candidates: 15.03.2011
Results publication at web sites: 31.03.2011

ADMISSION PROCEDURE
1) application reviewing

All applications will be reviewed by Admission Committee and short-listed candidates will be invited for an interview in English.
Following criteria will be used during the evaluation:
• The final note on Master Diploma of attended faculty – max 10 points
• The adequacy of the prepared letter of intent with the project– max 10 points
• International internship, Exchange, publications – max 5 points
• Participation in conferences / seminars – max 5 points
• English fluency – max 5 points

2) interview 

During the interview, the candidates should be prepared to answer questions related to the submitted letter of intent and content of the M. Sc. thesis, their scientific background and expertise, as well as some general questions. English fluency will also be verified.
The interview will be held at Faculty of Physics at Adam Mickiewicz University, in Poznan.
For candidates from abroad a teleconference will be organized if necessary. 

ADMISSION COMMITTEE & ASSESSMENT
The recruitment will be carried out by the Admission Committee, composed of 3 persons, selected from the would-be-tutors in the MPD: two from Physics Department of A. Mickiewicz University, one from Freie Universität Berlin. Admission Committee will prepare a final protocol with candidates’ assessment.

Postdoc in Yeast Protein Biochemistry,Aarhus University, Denmark

We are inviting applications for a postdoctoral project in yeast protein biochemistry at the Institute of Clinical Medicine, Aarhus University.

Our research is focused on the molecular characterization of cellular assemblies involved in human disease using yeast as model system. The project involves genetic tagging of yeast, purification of macromolecular complexes, biochemical and functional characterization and imaging of the isolates by molecular electron microscopy. We offer an interdisciplinary, dynamic environment and an excellent laboratory infrastructure with state-of-the-art equipment.

We are seeking a highly motivated individual with strong experience in protein purification and characterization. Previous experience in genetic tagging of yeast as well as protein production in yeast and bacteria is required. Experience in purification and characterization of large macromolecular assemblies is regarded as a plus.

Candidates must hold a Ph.D. or equivalent in biochemistry, molecular biology or a related subject. Good communication skills in spoken and written English are required. Further information about the project can be requested from Assistant Professor Bjoern Sander (bsander@ki.au.dk).

Applications should include a curriculum vitae, complete list of publications, list of oral and poster presentations, brief description of research experience and research interests (max. 2 pages) and a motivation letter. Please arrange for three letters of references to be sent under separate cover.

Applications are encouraged regardless of age, gender, race, religion or ethnic background. All applications must be sent via email to bsander@ki.au.dk and received by 11/02/2011.

Postdoctoral position in Molecular Oncology, Vall d'Hebron University Hospital Research Institute, Spain

We are currently looking for a highly motivated candidate to join the Group of Molecular Oncology at Vall d’Hebron Hospital, Barcelona, Spain (seehttp://www.vhir.org/gr/nanomolecularoncology). The successful candidate will join a translational research line aimed at the functional characterization of new genes involved in tumor progression. The candidate will be expected to join the group in early 2011.

THE CANDIDATE SHOULD:
- Have a doctoral degree in molecular biology or related fields.
- At least one year of postdoctoral experience is preferred.
- Good publication record in the field of Molecular Oncology.

WE OFFER:
- Postdoctoral position for one year that could be further extended.
- 25.000 Euros per year.
- Stimulating research environment.

CONTACT:
Please, contact Dr. Diego Arango before 30-January-2011: darango@ir.vhebron.net.

Postdoctoral Position, Institute for Medical Immunology, Université Libre de Bruxelles,Brussels,Belgium

Postdoctoral position at the Institute for Medical Immunology

A two-year postdoctoral position is available immediately in Pr Michel Braun’s laboratory at the Institute for Medical Immunology (IMI) of the University of Brussels (ULB), Belgium. The laboratory is working on understanding the biology of T cells chronically stimulated by persistent antigens. We aim at identifying new vaccine strategies that could control chronic immunological diseases.

The present project is funded by the Funds for Scientific Medical Research (FRSM) of Belgium. It focuses on the role played by miRNA-mediated gene regulation in T cells submitted to chronic antigenic stimulation. The successful candidate should have a PhD or equivalent with a strong background in molecular immunology. Experience in regulation of gene expression with small RNAs is desired but not essential.

The Institute for Medical Immunology is jointly funded by the Wallonia Region and GlaxoSmithKline Biologicals. The Institute offers excellent, well-equipped, laboratory space and extensive shared facilities, including SPF animal house, molecular biology lab, confocal microscopy, microarray plat-forms, mass spectrometry, flow cytometry and bio-imaging systems.

Qualified applicants should submit by email a single PDF application file, including a cover letter outlining research interests, CV, and the contact information of three referees tombraun@ulb.ac.be
Closing date for application is 15 February 2011

Postdoc Molecular Microbiology , Leibniz Institute for Natural Product Research and Infection Biology,Jena,Germany

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (HKI, www.hki-jena.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. We invite applications for a

Postdoc position

for three years initially.

Successful candidates will investigate the pathobiology of Aspergillus fumigatus within the framework of the international ERA-NET PathoGenoMics-project “OXYstress – Human fungal pathogens under oxygen stress: adaptive mechanisms to hypoxia and reactive oxygen species and their consequence for host interaction and therapy” starting in March 2011.

Main topics of the project are:

• Proteomics and transcriptomics of Aspergillus fumigatus

• Generation of mutant A. fumigatus strains

• Study of host-pathogen interactions

Requirements: Doctoral degree in biology, chemistry or life sciences. An excellent background in standard techniques of molecular biology, microbiology as well as biochemistry is expected. Knowledge of and hands-on experience in 2D-gel electrophoresis, microarray analysis, and infection biology are advantageous.

Salary is paid according to German TV-L depending on the applicants qualification. The HKI is an equal opportunity employer.

Further information:

Prof. Dr. Axel Brakhage • +49 (0)3641 532 1001 • axel.brakhage@hki-jena.de

Dr. Thorsten Heinekamp • +49 (0)3641 532 1095 • thorsten.heinekamp@hki-jena.de

Complete applications in German or English should include a CV, list of publications, brief statement of research experiences, a list of three potential references, and should be submitted until 09.02.2011 referring to HKI job posting No. 02/2011 to:

jobs@hki-jena.de

Mail address:

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie

– Hans-Knöll-Institut –

Personnel office

Beutenbergstrasse 11a

07745 Jena • Germany

PhD students – Stem cell differentiation and Cellular Reprogramming,Ulm University Hospital,Germany

DFG-funded Research Training Group GrK 1041

PhD students – Stem cell differentiation and Cellular Reprogramming

At the Department of Internal Medicine 1, Ulm University Hospital

Applications are invited for PhD student positions in the “Stem cell differentiation and Cellular Reprogramming” group, which has been established at the Centre of Internal Medicine, Department of Internal Medicine 1, University Hospital of Ulm. Research projects will be focused on the molecular biology and molecular endocrinology/diabetology underlying the perception and processing of embryonic and induced pluripotent stem cells to the pancreatic lineage. Techniques will involve cell culture, molecular genetics, biochemistry, imaging and viral gene transfer. For more information see also recent publications (Circulation. 2010 Nov 2;122(18):1823-36.). We enjoy a close working relationship with many excellent groups at the campus including the Institute of Molecular Medicine and Max-Planck-ResearchDepartment on Stem Cell Aging.

Application requirements:
The PhD position is a scholarship supported by the DFG-funded Research Training Group GrK 1041 and is based on a stipend. Currently positions are limited to a 2 year period. Applicants should by highly motivated and should have recently acquired a Master (PhD candidates) in the life sciences or related disciplines. In addition to being an enthusiastic scientist, we are seeking an individual who will collaborate with an international group of researchers to work on this highly complex and interdisciplinary topic.

The Ph.D. position is immediately available. Please send application documents to:

Bernhard O. Boehm, MD
Alexander Kleger, PhD
Department of Internal Medicine I,
Ulm University Hospital
Albert-Einstein-Allee 23
89081 Ulm, Germany
Phone: ++49-731-500-44728
Bernhard.boehm@uniklinik-ulm.de
Alexander.kleger@uni-ulm.de

Postdoctoral Scientist,Max Planck Society,Koln,Germany

Postdoctoral Scientist
(Code: 01/2011)

Is sought for a full-time position in the Department of Prof. Dr. Adam Antebi at the Max Planck Institute for Biology of Ageing, Cologne, Germany. The Antebi Department conducts research on how diet and hormones impact animal life span, using the worm Caenorhabditis elegans as a model. We seek a highly motivated and talented scientist to participate in a multi-disciplinary project focused on the systems biology of longevity pathways in C. elegans. The candidate should hold a Ph.D. degree, have a strong background in molecular biology, genetics and preferentially computational biology. They should have exceptional computer and organizational abilities, as well as excellent English writing and speaking skills. The expected start date is March 1, 2011. The Max Planck Institute for Biology of Ageing was founded in 2008 and is quickly becoming the centre of a unique network of research institutes dedicated to ageing related questions. A number of different model systems, including worms, flies, and mice, are used to address fundamental questions on the nature of ageing and age-related disease. The Institute offers an exciting international environment including employees from 23 different nations, with English as the working language in the laboratories. Compensation is according to the Public Service (TVöD federal) law, and depends on qualifications and experience. An initial contract will be offered for 2 years with a potential renewal for up to 4 years.

The Max Planck Society is an equal opportunity employer and is committed to employing more handicapped individuals and especially encourages them to apply. The Max Planck Society seeks to also increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

If interested, please send your complete application materials including a cover letter describing your scientific accomplishments and your interests in the lab, your CV and bibliography, contact info for at least 2 references, all in a single pdf-file online via our application portal until 07.02.2011.
Max-Planck-Institut für Biologie des Alterns
http://bewerberportal.age.mpg.de

PhD Studentship in Bioinformatics, University of Copenhagen , Denmark

PhD scholarship in Bioinformatics
Faculty of Life Sciences, University of Copenhagen
The Center for non-coding RNA in Technology and Health (http://rth.dk) is a newly established center with a multidisciplinary research strategy in the area of non-coding RNAs. The center has an open PhD position in bioinformatics, with start March 1st, 2011 or soonest thereafter. The duration for the position is three years.
Job description

Within recent years, it has become evident that non-coding RNAs (ncRNAs) play numerous important roles in the cell. Many ncRNAs contain a characteristic RNA structure, a hallmark that (albeit often at a high computational cost) can be exploited by in silico screens. These screens are in essence based on a search for RNA secondary structures. The goals of the Ph.D. project is to design methods to conduct in particular local structural alignments of RNA structures to be exploited for structure search in genomic sequence as well as structural clustering of the RNAs.
The project will be carried out in collaboration with people in the Center for non-coding RNA in Technology and Health.
Qualification requirements

The applicant should hold professional as well as personal skills and qualifications as stated below:
• A master degree in Bioinformatics, computational biology, biology or similar.
• Basic knowledge of biological sequences.
• Experience with algorithm development.
• Experience with Perl or Python (or similar)
• Experience with one (or more) of C, C++ or Java.
• It is an advantage (but not a requirement) to have general knowledge about RNA structure and folding, RNA gene search algorithms and algorithms for structural alignment or RNAs.
• The Ph.D. candidate should also possess good interpersonal skills.
Terms of employment

The position will be filled according to the Agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. The posts are covered by the Protocol on Job Structure.
The Ph.D. position requires the applicant to be approved for admission to the Ph.D. programme at LIFE when accepted for the position.
Questions

For further information about the post, please contact Center Director, Prof. Jan Gorodkin on tel. (+45) 3533 3578, gorodkin@rth.dk

General questions regarding Ph.D. programmes should be directed to the Course Administration c/o special advisor Michael Cleve Hansen, tel. + 45 3533 2056, or head clerk Lillian Zeuthen Bjørnseth on tel. +45 3533 2172. Further information on PhD programmes is available at www.life.ku.dk/English >Education > PhD Education > Regulations.
Application

The application MUST as a minimum include the following appendices 1-5 each clearly marked with the relevant appendix number:
Appendix 1: Cover letter, including an e-mail address for further communication.
Appendix 2: Curriculum vitae.
Appendix 3: Publications (if any).
Appendix 4: Complete transcript of university examinations.
Appendix 5: Contact information of two references.
Appendix 6 (optional): Other material the applicant might find relevant for the assessment.

Applications that do not include the required material may not be considered. The assessment committee may request further material from the applicant. Upon such request the applicant is obliged to send it to the committee.
Following processing of the application, all application material sent will be destroyed.
Receipt of the application will not be acknowledged, but the applicant will be kept continuously informed of the progress of the application.

The applicant will be assessed according to the Ministry of Science Technology and Innovation Executive Order no. 284 of 25 April 2008.
The application, marked 625/05172-310 should be sent to:

Center Coordinator Lotte Albret
Center for non-coding RNA in Technology and Health
Department of Basic Animal and Veterinary Sciences
Faculty of Life Sciences
University of Copenhagen
Grønnegårdsvej 3
1870 Frederiksberg C, Denmark
e-mail: lotte@rth.dk

The applications must be received latest by February 1st, 2011, at noon.Applications received after the closing time will not be considered.

The Faculty of Life Sciences is one of Europe’s leading university environments in the areas of food, health, plants, biotechnology, natural resources, the environment and related academic areas.
Our research and degree programmes are centred on knowledge and tools that can help secure a brighter future for humans, animals and plants.

Read more about The Faculty of Life Sciences at www.life.ku.dk

Postdoctoral Scientist, University of Freiburg School, Germany

The Brain Tumor Research Program at the University of Freiburg is recruiting a

Postdoctoral Scientist

Department of Neurosurgery, Neurocenter, Comprehensive Cancer Center Freiburg, University of Freiburg School of Medicine

The Brain Tumor Research Program at the University of Freiburg is recruiting an exceptional and highly motivated Postdoctoral Scientist for the research group of the Professor for Neuro-oncology (Markus Bredel, MD PhD), addressing the molecular biology, molecular genetics and resistance to therapy of human brain tumors.

We are looking for outstanding candidates with proven research credentials to expand on our recently published projects (NEJM: published online first, Dec 22, 2010; JAMA 302: 276-89, 2009; JAMA 302: 261-275, 2009).

Successful candidates will pursue research projects in areas that include:

1. Functional analysis of tumor suppressor genes and oncogenes using viral and non-viral gene delivery to identify transforming signaling pathway changes in brain tumors.

2. Identification and characterization of cancer stem cells derived from brain tumor samples and cell lines.

3. Brain tumor animal models.

We are interested in candidates with extensive molecular biology/genetics experience, including recombinant DNA technology, retroviral/lentiviral gene transfection and knockdown, cancer stem cell isolation/genetic modification, protein analyses, genotyping, primary tumor cell culture, and animal models. Candidates are expected to hold a doctoral (Ph.D.) degree in cancer biology/genetics and should have a strong desire to work in a dynamic, multidisciplinary environment.

Our group is part of the Translational Cancer Research Center Freiburg, one of only eight members of the German Consortium of Translational Cancer Research. Focusing on neuroscience, oncology, and functional genetics research, the University of Freiburg has one of the most extensive Brain Tumor Programs in Europe. The dynamic and integrative Brain Tumor Research Program is a leader in genomics analysis of human brain tumors. In addition to an exciting work environment and location in one of the most desired living spaces in Europe, we also offer a competitive salary and benefits package.

Interested candidates should submit via e-mail an electronic copy of their curriculum vitae, a cover letter describing their past research experience, along with complete contact information for at least three references to:
maria.carro@uniklinik-freiburg.de.

Postdoctoral Research Assistant in Bioinformatician,Queen Mary University of London,UK

!!!!! THIS JOB CLOSES 9 FEBRUARY 2011 !!!!!
INSTITUTE OF CANCER
Centre for Molecular Oncology and Imaging
Postdoctoral Research Assistant – Bioinformatician
This position represents an exciting opportunity to contribute to the development of the pancreatic cancer bioinformatics platform and analytical tools. The successful candidate will be expected to have strong numerical skills and a track record in the analysis of high throughput technologies.

Working mainly with R/Bioconductor and Perl, the successful candidate will be expected to address bioinformatics and statistical needs related to the design and analysis of profiling experiments. The successful candidate will additionally contribute to the release cycles as well as the wider development and extension of bioinformatics software tools within the Molecular Oncology and Imaging Centre.

Applicants should have a PhD degree in Bioinformatics or Computational Biology, a solid understanding and at least two years experience in the analysis of high throughput technologies, a comprehensive working knowledge of common bioinformatics tools and relevant statistical algorithms, and should have demonstrated the ability to apply that knowledge to help unravel the molecular basis of a disease.

The successful candidate must be an expert in high throughput data manipulation, analysis and visualisation using R and the programming language Perl. Experience of additional languages, e.g. Java or C, would be highly desirable. Familiarity with Linux network/server administration and web application development technologies will be an advantage. Proficiency in the use of relational databases, in particular MySQL is essential. Experience in molecular biology, genetics, or cancer research is essential.

It is also essential that the candidate has clear communication skills, with the ability to present methodologies and results succinctly and to provide advice, training and support for researchers.

This is a full-time, fixed term appointment for 3 years. The starting salary will be in the range of £30,229 – £33,695 per annum inclusive of London Allowance. The benefits package for this post includes 30 days leave plus 4 College closure days, flexible working hours, childcare vouchers scheme, contributory final salary pension scheme and an interest free season ticket loan.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Informal enquiries about this post, including arrangements to visit the Centre, can be made to Dr. Claude Chelala, tel: 020 7882 3570 or email: c.chelala@qmul.ac.uk.

Application enquiries should be directed to Charterhouse Square Recruitment at
csq-recruit@qmul.ac.uk.

To apply, please visit the Human Resources website onhttp://www.hr.qmul.ac.uk/vacancies and search by post reference number QMUL0311.
The closing date for the applications is on the 9 February 2011
Valuing Diversity & Committed to Equality

Postdoc in Computational Model Analysis and Knowledge Representation, Karolinska Institutet,Sweden

Area of responsibilities/description of the work

A three year (1+2) postdoctoral position, funded by an FP7 project – SYNERGY, is open. The position targets semantic mapping and analysis of 5 available computational ODE models of the lung, skeletal muscle and the heart at different organization levels. This work is part of the larger SYNERGY project funded by the European VPH initiative (see http://www.vph-noe.eu/). The work is performed in collaboration with leading researchers in Europe and Spain in particular, aiming to develop a simulation environment and a decision-support system aiming at enabling deployment of systems medicine. The three core elements are a knowledge base (KB), an inference engine (IE), and a graphical visualisation environment (GVE). The SYNERGY project focuses on patients with chronic obstructive pulmonary disease (COPD). The successful applicant will work in WP3 and WP5 on the knowledge base and model integration and analysis. The available models will be annotated and further analyzed and linked to the knowledge base. Supplementary Bayesian Network modelling will be performed.

The position is located at the Unit for Computational Medicine (www.compmed.se), at the Department of Medicine, Solna, Karolinska Institutet. The Unit is physically located at the Center for Molecular Medicine (CMM) (www.cmm.ki.se) that offers an outstanding research environment and possibilities for collaboration in the field of complex common diseases.

Qualifications

Applications are invited from highly talented and enthusiastic researchers with a PhD degree or a foreign qualification deemed equivalent to a doctorate. A strong background in computational science is required. The ideal candidate will be experienced in computational ODE modeling, semantic techniques, ontologies, Bayesian Network modeling and programming. Tools and languages such as C++, script languages, SBML, and semanticSBML are essential. Broad knowledge of computer science and machine learning methods is required. Experience with computational biology, systems biology and biology, as well as documented ability to work in collaborative projects is meriting. Interest in the overall VPH project – approach and tools is meriting. Good knowledge of spoken and written English is required.

To qualify, the applicant must hold a doctor’s degree or a foreign qualification deemed equivalent to a doctorate. Applicants who have completed their degree no more than three years before the last date for applications should be given priority. Candidates who have completed their degree earlier than this should receive equal priority if special grounds exist.

Postgraduates who have yet to graduate may apply if their public defense is scheduled to take place within three months after the application deadline, in which case verification from the Dissertation Committee or equivalent body must be submitted with the application.

Form of employment:

Temporary

Contact persons

For further details about the research project please contact:

Jesper Tegnér, Professor

Phone: +46 70-680 49 89

E-mail: jesper.tegner@ki.se

For conditions, please contact:

Pernilla Appelquist, Executive Assistant, Unit for Computational Medicine.

Phone: +46 8-517 708 69

E-mail: pernilla.appelquist@ki.se

Union representatives:

OFR

Merja Heinonen

Phone: +46 8-517 753 97

E-mail: merja.heinonen@ki.se

SACO

Michael Fored,

Phone: +46 8-517 791 81

E-mail: michael.fored@ki.se

Please send your application, marked with reference number 07297/2010, to reach us by no later than January 31 2011 to KI jobb or,

to Karolinska Institutet, Institution of Medicine, Att Helene Utterberg, Norrbacka S3:01, 171 76, Stockholm, E-mail: rekrytering@meds.ki.se. The following documents must be submitted with your application, and written in English or Swedish:

1. A full CV, including date of public defense, title of thesis, previous academic appointments,

academic title, current position, academic distinctions and committee work

2. A full publication list

3. A brief outline of your current work (max. one page)

See Karolinska Institutet´s homepage at http://ki.se/qualificationsportfolio for information about the qualification portfolio.

Please note that one copy of all documents will be kept by the college for a period of two years, in accordance with a directive from the National Archives. Published material submitted for review is excepted from this rule.

Karolinska Institutet aims to promote equal opportunities by encouraging a balanced gender distribution. We also value the qualities that ethnic and cultural diversity can contribute to the university.

The Department of Medicine consists of 14 Units including 350 employees and 160 PhD students, The Center for Molecular Medicine (CMM) gathers more than 400 members performing research on the common diseases. The philosophy of CMM is to foster innovative research within the core areas of the center, both from using unique features of our clinical connection (extensive clinical material and clinical competence) and from being part of KI with its international reputation and excellent basic research.

Karolinska Institutet is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

Post doc Position in miRNA Biology, University of Copenhagen

Post doctoral position in miRNA biology


The Department of Biology, University of Copenhagen, is recruiting a post doctoral researcher for a 2-year project to work on mechanisms of microRNA (miRNA) action in the newly established research group of Peter Brodersen. The starting date is April 1st 2011 or as soon as possible thereafter. The group is housed in the recently inaugurated Biocenter in central Copenhagen, Denmark (http://www.biocenter.ku.dk/).

The group uses the plant Arabidopsis thaliana to study mechanisms employed by miRNAs to regulate gene expression. The successful candidate will investigate the association of the silencing machinery with membrane compartments using primarily biochemical and genetic approaches. A major goal of the project is to identify and characterize novel factors required for membrane recruitment of the silencing machinery.

We are looking for a highly motivated individual with a Ph.D. degree in molecular biology or equivalent. Experience with protein purification in addition to standard molecular biological skills will be considered an advantage, but is not a formal requirement. The applicant must be fluent in written as well as spoken English. The position is open to all applicants regardless of nationality, and will be funded by a grant from the Novo Nordisk Foundation.

Terms of appointment and payment are in accordance with the agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC). Post doc salary is based on seniority and is between DKK 376.923 and DKK 396.851 (roughly between EUR 50.500 and EUR 53.000) annually before pension contribution. Negotiation for further supplement will be possible.

Applications should be sent as a single pdf file to Job15@bio.ku.dk marked “211-0055/11-5550” no later than February 14, 2011 and must contain the following sections: A 1-page letter explaining the applicant´s background and reasons for applying, a 1-page curriculum vitae, a list of peer-reviewed publications (may include papers under review), master diploma including grades, Ph.D. diploma including any evaluation if applicable. Letters of recommendation may be included at the end of the application. In addition, a signed hardcopy of the application must be posted to “Peter Brodersen”, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.

For further information on the project contact Associate Professor Peter Brodersen, e-mail pbrodersen@bio.ku.dk

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.

Postdoctoral Grant in Molecular Biology,University of León, Spain

Requirements: PhD (attained after 2007 or before July 2011) and molecular biology skills.
Note: expires by February 1st.

The researcher will work with qPCR and proteomics techniques to assess DNA damage in histone-rich and protamine-rich regions of mammal spermatozoa, measure changes in telomere lenght and detect the presence of the apoptotic marker PARP and caspases. Most of the work deals with molecular biology techniques (DNA work, PCR) and cell biology (flow cytometry, immunostaining).

The grant application will open by February 2011. It is a public call for carrying out a 3-year post-doc in Spain. Candidates are selected by July. It is a very competitive process, thus a good CV is required (especially publications in peer-reviewed journals).

Postdoc in Experimental Cellular Immunology, Karolinska Institutet, Stockholm, Sweden

Area of responsibilities/description of the work
This postdoctoral position involves establishing cell culture systems for primary human lymphocytes and carrying out cell differentiation and stimulation experiments as well as RNA interference studies on these cells. This work is part of a larger initiative by our group, in collaboration with leading researchers at Karolinska Institutet, aiming to comprehensively phenotype immune cell activities on the transcriptional, proteomic, and metabolic levels. A portion of the work will be performed abroad, in collaboration with leading groups at Harvard Medical School in RNA interference methodology using primary cells. The position is for 2 years with good possibilities for extension.

The position is located at the Unit for Computational Medicine (www.compmed.se), at the Department of Medicine, Solna, Karolinska Institutet. The Unit is physically located at the Center for Molecular Medicine (CMM) (www.cmm.ki.se) that offers an outstanding research environment in the field of complex disease.

Qualifications
Applications are invited from highly talented and enthusiastic researchers with a PhD degree or a foreign qualification deemed equivalent to a doctorate. A strong background in mammalian cell biology is required. The ideal candidate will be experienced in leukocyte biology, in particular T cell differentiation and activation, and familiar with handling primary human cells. Broad knowledge of cell and molecular biology methods and documented ability to lead research projects are requirements. Experience with co-culture techniques, cell proliferation and T-cell activation assays, as well as documented ability to work in collaborative projects is meriting. Good knowledge of spoken and written English is required.

To qualify, the applicant must hold a doctor’s degree or a foreign qualification deemed equivalent to a doctorate. Applicants who have completed their degree no more than three years before the last date for applications should be given priority. Candidates who have completed their degree earlier than this should receive equal priority if special grounds exist.

Postgraduates who have yet to graduate may apply if their public defense is scheduled to take place within three months after the application deadline, in which case verification from the Dissertation Committee or equivalent body must be submitted with the application.

Form of employment:
Temporary

Contact persons
For further details about the research project please contact:

Jesper Tegnér, Professor
Phone: +46 70-680 49 89
E-mail: jesper.tegner@ki.se

For conditions, please contact:
Pernilla Appelquist, Executive Assistant, Unit for Computational Medicine.
Phone: +46 8-517 708 69
E-mail: pernilla.appelquist@ki.se

Union representatives:
OFR
Merja Heinonen
Phone: +46 8-517 753 97
E-mail: merja.heinonen@ki.se

SACO
Michael Fored,
Phone: +46 8-517 791 81
E-mail: michael.fored@ki.se

Please send your application, marked with reference number 07296/2010, to reach us by no later than February 8 2011 to KI jobb or,
to Karolinska Institutet, Institution of Medicine, Att Helene Utterberg, Norrbacka S3:01, 171 76 Stockholm, E-mail: rekrytering@meds.ki.se.

The following documents must be submitted with your application, and written in English or Swedish:
1. A full CV, including date of public defense, title of thesis, previous academic appointments,
academic title, current position, academic distinctions and committee work
2. A full publication list
3. A brief outline of your current work (max. one page)

See Karolinska Institutet´s homepage at http://ki.se/qualificationsportfolio for information about the qualification portfolio.

Please note that one copy of all documents will be kept by the college for a period of two years, in accordance with a directive from the National Archives. Published material submitted for review is excepted from this rule.

Karolinska Institutet aims to promote equal opportunities by encouraging a balanced gender distribution. We also value the qualities that ethnic and cultural diversity can contribute to the university.

The Department of Medicine consists of 14 Units including 350 employees and 160 PhD students, The Center for Molecular Medicine (CMM) gathers more than 400 members performing research on the common diseases. The philosophy of CMM is to foster innovative research within the core areas of the center, both from using unique features of our clinical connection (extensive clinical material and clinical competence) and from being part of KI with its international reputation and excellent basic research.

Karolinska Institutet is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

PhD in Modeller in Systems Biology of Ageing,Otto von Guericke University, Germany

The Institute of Experimental Internal Medicine offers a position for

1 Postgraduate (PhD) (E13/2,TV-L)

for a Modeller, Physicist, Applied Mathematician or the like in an interdisciplinary project on Systems Biology of Aging.

The overall project focuses on the experimental and theoretical analysis of stress induced cellular senescence. The PhD position, however, mainly focuses on the modelling and theoretical aspects. Therefore, applicants with a background in Systems Biology, Biophysics or Mathematical Biology, who are interested to work in a highly interdisciplinary environment, are strongly encouraged to apply. A basic knowledge of ODE systems and statistics is a prerequisite. The position offers the opportunity to obtain a doctoral degree (PhD). The position is for three years initially with the possibility of an extension of 2 years.

The institute coordinates and participates in a variety of coordinated programs funded by the German Research Foundation (GRK1167, SPP1365, FOR521, SFB779, SFB854), the Federal Ministry of Education and Research (SysTec) and the European Union (Marie Curie Research Training Networks). Further, the institute is member of the interdisciplinary “Research Center Dynamic Systems: Biosystems Engineering (CDS)”” funded by the Federal State of Saxony-Anhalt within the “Excellence Program” and the “Magdeburg Center of Systems Biology MaCS)” funded by the Federal Ministry of Education and Research within the „FORSYS“ program “Research Units in Systems Biology”.

The Otto von Guericke University wishes to increase the proportion of female academic personnel. Women are therefore explicitly encouraged to apply. Handicapped persons with equivalent qualification will be given preference.

For further information please fell free to contact Dr. Jörg Schaber (schaber@med.ovgu.de).
Please send a motivation letter, CV, publication list and two references in ONE SINGLE PDF-file to Dr. Jörg Schaber (schaber@med.ovgu.de) until 22.2.2011.

PostDoc in cell biology of cardiovascular disease in University of Heidelberg, Germany

A post-doctoral research position is available immediately for an exciting, interdisciplinary research project at Heidelberg University Medical Faculty and the European Molecular Biological Laboratories (EMBL).
The successful candidate will conduct a challenging research project that aims at the molecular characterization of genes pre-disposing for elevated blood cholesterol levels, a major risk factor for atherosclerosis and coronary heart disease. Specifically, the project seeks to investigate the cell biological and pathogenic function of selected candidate genes that have been identified in recent genome-wide association studies (GWAS) as associated with blood lipid traits. For this, the candidate will apply technologies developed in our laboratories that now make it possible to accomplish detailed cell-based loss-of-function studies of many genes in parallel using state-of-the-art microscopy.

The project is part of the prestigious transatlantic research alliance Molecular mechanisms of novel genes associated with plasma lipids and cardiovascular disease funded by the Fondation Leducq (http://www.fondationleducq.org/index.php). The position will be hosted within the stimulating international environment of the Molecular Medicine Partnership Unit (MMPU), a successful joint venture between the Medical Faculty of the University of Heidelberg and EMBL with the mission to strengthen the link between molecular research and medicine (http://www.klinikum.uni-heidelberg.de/MMPU).

We seek highly motivated candidates, ideally with qualifications in the areas of cell biology, functional genomics, bioinformatics and molecular medicine. The position is funded for an initial 2 years, but may be extendable for up to 5 years.

Contact:
Heiko Runz (heiko.runz@med.uni-heidelberg.de)
Institute of Human Genetics
Molecular Medicine Partnership Unit (MMPU)
INF 366, 69120 Heidelberg, Germany
http://www.klinikum.uni-heidelberg.de/Cholesterol-Regulation.114487.0.html
http://www.embl.de/research/partnerships/mmpu/research_groups/cholesterol_regulation/index.html
References:
Bartz, F. et al. Identification of cholesterol regulating genes by targeted RNAi-screening. Cell Metabolism (2009) 10:63-75.
Neumann, B. et al. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 464:721-727.

PhD in Physical Organic Chemistry, University of Edinburgh, Denmark

Primary supervisor: Dr Scott L. Cockroft,
Second supervisor: Prof. David A. Leigh FRS

This is a tax-free stipend covering tuition fees for a successful UK/EU/Swiss applicant and living expenses at the standard EPSRC rate (commencing at ~£13,590 per year from the 1st September 2011 for a period of 3 years). Scholarships are also available to outstanding applicants from outside the UK/EU/Switzerland as detailed below.

Project:

Non-covalent interactions are fundamental aspects of almost all chemical and biological processes. Solvent effects coupled with the precise positioning of interacting functional groups may be essential for the astonishing ligand binding affinities observed in biology. However, previous experimental studies concerning the influence of solvent shape and geometric positioning of interacting functional groups have been particularly limited. The aim here is to design and synthesise new supramolecular complexes quantifying the interplay of geometry and solvation effects on non-covalent interactions. Particular attention will be paid to solvent-excluded hydrogen-bonding.
The student working on this project will receive training in a range of modern experimental and analytical techniques associated with physical organic chemistry including:
• organic synthesis
• theoretical background in molecular recognition
• NMR spectroscopy
• quantitative structure activity relationships
• computational modelling and ab initio calculations

Applications:
Applicants should express a keen interest in organic synthesis, supramolecular chemistry and molecular recognition. Applicants should be in possession of (or expecting to obtain) a first class or upper-second class degree (or equivalent) in chemistry or other cognate discipline before the 1st Oct ‘11. All applicants should email a copy of their CV to scott.cockroft@ed.ac.uk. Please include a brief description of previous research experience, and the contact details of two referees.
Applications should be made as soon is as possible such that scholarship applications can be prepared where appropriate (deadlines 1st Feb ‘11). However, applications received as late as 1st March ‘11 may still be considered.

UK/EU/Swiss applicants, should ideally apply for an EaStChem research excellence scholarship before the 1st February deadline in addition to the application procedure detailed above:
http://www.ed.ac.uk/schools-departments/student-funding/postgraduate/uk-eu/science-engineeering/chemistry/eastchem

Outstanding applicants from outside of the UK/EU/Switzerland, may be eligible for overseas scholarships that will either fully cover overseas tuition fees or reduce them by £5,000 per annum, and they should contact scott.cockroft@ed.ac.uk as soon as is possible to explore these possibilities.

Further information: http://homepages.ed.ac.uk/scockrof/research.php

Informal enquiries should be directed to scott.cockroft@ed.ac.uk
Tel: +44 (0)131 650 4758.