To strengthen our team in studying protein networks and protein function in health and disease in the group of Prof. Marius Ueffing, Center of Ophthalmology and Medical Proteome Center, University of Tübingen we are looking for
1 Scientific Project Manager -3 Postdoctoral Researchers -1 PhD student
Within the Centre of Ophthalmology, the Medical Proteome Center Tübingen is a state of the art facility for mass spectrometric analysis of proteins and protein complexes. Our main focus lies on the identification of disease mechanisms, mainly by the determination of disease-causing influences like mutations, on protein complexes and networks. Therefore, we are developing and applying novel technologies for protein and protein complex analysis. We offer the possibility to work in a highly motivated team of scientists and a stimulating atmosphere with the access to state of the art mass spectrometers. Additionally the EU-funded projects offer the great possibility to collaborate with leading scientists in cilia biology, cancer research or protein complex purification and analysis.
Positions
The scientific coordinator will support the head of the institute as well as our team, participate in planning and developing projects and grant proposals, monitor projects (timing and processing), stay in contact with partners and adjust projects according to their needs. The successful applicant will be expected to interact closely with the director as well as project leaders within the Center of Ophthalmology, Institute of Ophthalmic Research, Tübingen. Fluent correspondence in English is essential, and German would be advantageous. We seek a creative, flexible and highly motivated candidate with a PhD in the life sciences, preferentially genomics/genetics, molecular biology or biochemistry, with post-doctoral or group leader experience. Good communication skills are essential. Laboratory experience in proteomic and molecular technologies or in bioinformatics is advantageous. The position will be for two years with the possibility for extension and permanence.
The postdocs as well as the PhD student will have the opportunity to work within the frame of internationally positioned, EU-funded, large scale collaborative FP7-projects (Syscilia, AFFINOMICS, PRIMES).
The ideal postdoctoral candidate has either a strong background in protein complex analysis, cancer or cilia biology. Excellent communication skills in English are an absolute requirement as well as the ability to work in a team. A high degree of self-motivation and interest in scientific projects is essential. Experience in mass spectrometry, especially targeted, absolute quantification would be a strong advantage. Contracts will be issued for initially two years with the possibility of further prolongation.
The ideal PhD student has an excellent master degree in biology, biochemistry or a related field. Excellent communication skills in English are a must. The candidate should be highly motivated and have interest and knowledge in cancer biology and quantitative, mass spectrometric analysis of protein complexes.
Project descriptions
Project 1: 1 postdoctoral position The Syscilia consortium (http://www.syscilia.org/) aims to identify the molecular mechanisms, characterizing ciliary function as well as the perturbations leading to the large group of ciliopathies. To achieve this, a systems biology based approach, bringing together different partners from different disciplines, is applied. Within this project, we will use affinity purification of protein complexes combined with quantitative mass spectrometry to determine the ciliary protein network and investigate how factors, leading to disease, act on this (Boldt et al, J Clin Invest, 2011).
Project 2: 1 postdoctoral position The goal of AFFINOMICS is the development and application of novel affinity binders in close collaboration with leading scientists in the field. We will get access to highly validated affinity binders, mainly for the analysis of protein complexes and networks of kinases, phosphatases and SH2 proteins involved in cell-cycle control, differentiation and cell survival (Gloeckner et al, Proteomics 2007).
Project 3: 1 postdoctoral and 1 PhD position The in-depth systems biological analysis of a cancer associated protein signalling network will be final outcome of this project and it will be conducted with cancer specialists all over Europe. To achieve this, we will investigate this signalling network, as well as the effect of drugs on the network in depth by the application of quantitative protein complex analysis (Meixner et al, Mol Cell Proteomics, 2011; Gloeckner et al, Proteomics 2007).
UKT is an equal opportunity employer: Handicapped individuals are strongly encouraged to apply, and so are women in areas in which they are underrepresented. Payment and benefits are according to TVL and depend on previous experience.
To apply, please e-mail a single pdf file that contains 1) letter of 1-2 pages that describes your research interests and experience, 2) curriculum vitae, and 3) the names of at least two academic references, including their contact information, to
Please send your application by e-mail to
Dr. Karsten Boldt / Prof. Dr. Marius Ueffing
E-mail: karsten.boldt@uni-tuebingen.de
Centre for Ophthalmology
Institute for Ophthalmic Research
Naegelestr. 5
D-72074 Tuebingen
Germany
The appointment will be realized by the personnel department.