Doktorand zum Thema Actin in cell dynamics and epithelial remodelling ,Göttingen, Germany

Our laboratory investigates molecular and genetic mechanisms responsible for
morphogenesis/structure formation in early Drosophila embryos, including
polarisation and formation of the plasma membrane, organisation and dynamics of
the actin cytoskeleton and microtubules and nuclear size, shape and position. In
 our experiments we employ various live imaging techniques in combination with
 molecular and genetic approaches. Funding for two postions is available:

1. Dynamics of cell contacts and function of actin in epithelial cell intercalation.
This project is part of a newly established DFG Forschergruppe ("Functional
dynamics of cell contacts" ).

2. Molecular function and regulation of actin nucleators of the Formin family. This
project is part of the DFG priority programme (SPP "Function and evolution of actin
 nucleators")

The candidates should have a master/Diplom degree in biology or related subjects
 and should be interested in performing a challenging research project as part of an
 international team and within the Göttingen Graduate School (GGNB,
 www.ggnb.uni-goettingen.de), which provides a structured educational programme
 for graduate students. Please contact or send your application (CV, names of
references, copies of certifcates) to Prof J Großhans,  jgrossh@gwdg.de, 0551-
398242)

2 PhD positions -Actin in cell dynamics and epithelial remodelling ,Göttingen,Germany

Our laboratory investigates molecular and genetic mechanisms responsible for
morphogenesis/structure formation in early Drosophila embryos, including polarisation and
formation of the plasma membrane, organisation and dynamics of the actin cytoskeleton and
microtubules and nuclear size, shape and position. In our experiments we employ various live
imaging techniques in combination with molecular and genetic approaches. Funding for two
 postions is available:

1. Dynamics of cell contacts and function of actin in epithelial cell intercalation. This project is
part of a newly established DFG Forschergruppe ("Functional dynamics of cell contacts" ).

2. Molecular function and regulation of actin nucleators of the Formin family. This project is
part of the DFG priority programme (SPP "Function and evolution of actin nucleators")

The candidates should have a master/Diplom degree in biology or related subjects and should
 be interested in performing a challenging research project as part of an international team and
 within the Göttingen Graduate School (GGNB, www.ggnb.uni-goettingen.de), which provides a
structured educational programme for graduate students. Please contact or send your
application (CV, names of references, copies of certifcates) to Prof J Großhans,
 jgrossh@gwdg.de, 0551-398242)

3-year Ph.D. position at the University of Cologne, Germany (Cologne, Germany)

3-year Ph.D. position at the University of Cologne, Germany

Multi-scale subtropical controls on the position and intensity of the summertime West African heat low

Main supervisor: Prof. Dr. A. H. Fink (University of Cologne, Cologne, Germany, fink@meteo.uni-koeln.de)

Co supervisor: Dr. Peter Knippertz (University of Leeds, Leeds, United Kingdom, p.knippertz@leeds.ac.uk)

Starting date: immediately

The summertime West African heat low (WAHL) over the western Sahara desert exerts a strong control on the continental-scale monsoon circulation and thereby, e.g., affects rainfalls over the Sahel. Until recently the lack of observational data has hindered our understanding of the WAHL dynamics, leading to comparably limited capabilities to predict the West African monsoon. The proposed PhD project will directly benefit from exciting new field activities in this region. The international Fennec field campaigns in 2011, and potentially in 2012, provide unprecedented surface, upper-air, and aircraft data. In addition, the University of Cologne has been operating a unique meso-network of Automatic Weather Stations (AWS) in the Drāa valley of south-eastern Morocco. The PhD student is expected to play an active role in operating, processing and archiving the AWS data including several visits to the field sites. The research aims at a better understanding of the meteorological proc!
 esses on the subtropical side of the WAHL that control its position and intensity. In the long run, this work will help to improve weather and climate predictions in this largely understudied region.

  The successful candidate will conduct both diagnostic and modelling work. He/she will perform a synoptic-dynamic analysis of upper-level disturbances over northwest Africa, deep moist convection over the Atlas Mountains and density currents that are created through the cooling associated with the evaporation of convective precipitation. These density currents can penetrate far into the northern Sahara and are suspected to contribute to the ventilation of the WAHL adding to the well known synoptic-scale ventilation from the Atlantic Ocean and the Mediterranean Sea. Another focus is the so called Atlas and Hoggar pumping hypothesis, i.e. (moist) convection and uplift over these mountains amplify the subsidence in the core region of the WAHL. For both research questions, sensitivity experiments will be carried out using the Weather Research and Forecasting (WRF) model.

The PhD student will be part of Prof. Dr Andreas Fink's lively and supportive research group (http://www.geomet.uni-koeln.de/en/general/the-institute/research-groups/research-group-fink/). The group is based at the Institute of Geophysics and Meteorology at the University of Cologne. Cologne is the fourth largest city in Germany with a rich cultural life and recreational value. Multi-week research visit at Leeds (UK) to work with Dr. Knippertz group are envisaged. The student will also benefit from the active involvement in the international FENNEC science team.

Application

The successful candidate should have a Master of Science equivalent university degree in meteorology or a physical or mathematical discipline, such as mathematics, physics, geophysics, and engineering. Experience in synoptic-dynamic meteorology and/or atmospheric modelling, with working in a Linux environment, with scientific programming in FORTRAN 90 and/or C is highly desirable.

The position (50%, 19.92 hours/week, TV‐L E13) is awarded for 3 years. Review of applications will begin immediately and continue until the position has been filled.

Equal employment opportunity: Selection for these positions will be based solely on merit without regard to gender, religion, national origin, political affiliation, marital or family status or other differences. Among equally qualified candidates, handicapped candidates will be given preference.

Please send inquiries and applications (with a meaningful CV) to (e-mail applications are preferred):
Prof. Dr. Andreas Fink
Institute of Geophysics and Meteorology
University of Cologne
D-50923 Cologne, Germany
fink@meteo.uni-koeln.de

Plase also see:

<http://www.stellenwerk-koeln.de/uploads/tx_exinitswkjobs/PhD_Geophysik.pdf>

4 PhD Scholarships in Structural Biology (Duesseldorf, NRW, Germany)

The NRW Research School BioStruct – Biological Structures in Molecular
Medicine and Biotechnology at Heinrich-Heine-University Düsseldorf in
Germany, funded by the Ministry of Innovation, Science, Research and
Technology of the German Federal State North Rhine-Westphalia (NRW),
and the school chairmen Prof. Dr. Lutz Schmitt and Prof. Dr. Dieter
Willbold invite applications for a PhD Scholarship starting in October 2011.

BioStruct offers innovative PhD education and research programs within
a stimulating interdisciplinary environment combining the field of
structural biology with molecular medicine and biotechnology.
Highly motivated and excellent candidates holding an MSc or Diploma
degree in the fields of Biochemistry, Biology, Chemistry, Physics and
related fields can directly apply for a scholarship including a
monthly stipend of 1345,- EUR and contributions towards travel and
research expenses.

1. PhD Scholarship for ‘Structural studies on molecular interactions
of the Disrupted-in-schizphrenia (DISC1) protein'

The ideal candidate will have a background in protein biochemistry
and/or biophysical characterization of proteins. Basic knowledge
and/or experience in crystallization and X-ray spectroscopy would be
an advantage. A strong interest in structural biology is a
prerequisite. We are looking for an enthusiastic and highly motivated
individual with fluency in written and spoken English, an open mind
for new approaches and a lot of team spirit.
Workplace will be the “University hospital Düsseldorf” at
Prof. Dr. Korth's Lab
/Research Group Neurodegeneration Neuropathology.
PhD Research Project Summary: The molecular causes of schizophrenia
are still unknown. Recently, based on several genetic studies, the
disrupted-in-schizophrenia 1 (DISC1) protein has come into focus for
investigating molecular mechanisms of schizophrenia and other mental
diseases. Here, structural and quantitative investigations of DISC1
with its interacting centrosomal molecules NDEL1, NDE1, PDE4B and LIS1
are proposed. All proteins, or soluble representative fragments
thereof, as well as mutant / polymorphic counterparts will be
expressed in Escherichia coli. Structural studies will be attempted by
NMR and crystallography for single and complexed proteins and
complemented by binding studies with surface plasmon resonance.
These investigations will yield insight into the stochiometry and
regulation of the interactions in the DISC1/NDEL1/NDE1/LIS1/PDE4B
complex, and, through structural determination of binding interfaces,
open novel pharmacological targets for these diseases.

2. PhD Scholarship for ‘Protein Structure Determination of
Proton-translocating pyrophosphatases using X-ray crystallography’

The ideal candidate will have a background in membrane protein
expression and purification as well as in biophysical characterization
of proteins. Basic knowledge and/or experience in protein
crystallisation would be an advantage. A strong interest in structural
biology is a prerequisite.
Workplace will be the “Heinrich Heine University Düsseldorf” in the
group of Prof. Dr. Georg Groth.

PhD Research Project Summary: Transmembrane proton pumping is
responsible for many physiological processes including the generation
of proton motive force that drives bioenergetics. Among the various
proton pumping enzymes, vacuolar pyrophosphatases (V-PPases) form a
distinct class of proton pumps, which are characterised by their
ability to translocate protons across a membrane by using inorganic
pyrophosphate (PPi) instead of ATP as an energy source.

The project will be directed at gaining a fundamental understanding of
the structure and molecular mechanism of inorganic pyrophosphate-
(PPi-) energized proton pumps using x-ray crystallography.

3. PhD Scholarship for ‘Structure and function of the Chlamydia
adhesins OmcB and Pmp21'

The ideal candidate will have a background in protein biochemistry and
biophysical characterization of proteins. A strong interest in
infection biology as well as in structural biology is a prerequisite.
Workplace will be the “Heinrich Heine University Düsseldorf” in the group of Prof. Dr. Johannes Hegemann.

PhD Research Project Summary: Chlamydiae are obligate intracellular
bacterial pathogens which cause a variety of important human diseases.
Chlamydia trachomatis is the most common bacterial agent of sexually
transmitted diseases and is responsible for over 90 million new
infections every year worldwide. The C. trachomatis ocular serovars
are responsible for trachoma, the major cause of preventable blindness
in developing countries. Acute C. pneumoniae infections cause
pulmonary diseases (e.g. 10 % of all pneumonia incidents worldwide),
whereas the chronic infection is linked to atherosclerosis and artery
disease. The chlamydial infection starts with the adhesion of the
bacteria to the human cell by binding of bacterial adhesins to
eukaryotic receptors.

We have identified and characterised the first chlamydial adhesin
proteins which interact with the human cell. The OmcB protein binds to
heparan sulfate-like glycosaminoglycan (GAG) structures on the human
cell surface. Single amino acids in the GAG-binding domain of OmcB are
essential for adhesion to human cells and may determine cell tropism
and disease pattern for different C. trachomatis serovars (systemic
versus local infection). The second adhesin recently identified
consists of a family of 21 related polymorphic membrane proteins (Pmp)
unique to Chlamydiae, whose human cell surface receptor has just been
identified. Pmp proteins are anchored in the bacterial membrane and
their N-termini carry several independent adhesion domains.

Analysis of the three-dimensional structure of the adhesins OmcB and
Pmp21 (as prototype) will form the basis for a molecular understanding
of the interactions of these proteins with their human receptors and
will facilitate identification of small molecule inhibitors.

4. PhD Scholarship for the project "Conformational dynamics and
structure of biomolecules studied by super-resolution Förster
Resonance-Energy-Transfer (FRET)"

The ideal candidate will have a background in biophysical principles
of biomolecular function (RNA and proteins). A strong interest in
structural biology and fluorescence spectroscopy is a prerequisite.
Workplace will be the “Heinrich-Heine-University” in the group of
Prof. Dr. Claus Seidel.

PhD Research Project Summary: While X-ray crystallography reveals
snapshots of biomolecules at atomic resolution, many biomolecules are
inherently dynamic. In some cases, low populated conformational states
are overlooked or simply not accessible using conventional structural
biology tools.
FRET that is considered a low-resolution tool has not yet received
much attention in the field. However, recent developments in Prof.
Seidel's group have shown the ability to reconstruct nucleic acid
structures using super-resolution FRET [Methods in Enzymology 475,
455-514 (2010), J. Am. Chem. Soc. 133, 2463-2480 (2011)].
We propose to use these recent tools ensemble and single-molecule
spectroscopy to determine super-resolution FRET structures of multiple
conformational states in biomolecules. A special focus is on detailed
characterization and 3D architecture of helical structures. Using all
fluorescence techniques the 3D structures of complex, temperature
sensitive regulatory RNA "thermometers" with a varying number of stem
loops shall be solved in this project. Moreover we will use these
tools to study helix bending und rotation of transmembrane helices in
membrane proteins studied in our group.

For further information on the NRW Research School BioStruct,
prerequisites and mandatory application forms
please visit our website:

www.biostruct.de

Application Deadline: August 26th, 2011 Only complete applications according to the BioStruct application regulations will be considered. For further information please visit: www.biostruct.de

Application details: http://www.uni-duesseldorf.de/home/Fakultaeten/math_nat/Graduiertenkollegs/biostruct/Application/Scholarship

2 Ph.D positions microbial diversity and ecosystem functioning 100%

2 Ph.D positions “microbial diversity and ecosystem functioning” 100%

Organisations
Research Station Agroscope Reckenholz-Tänikon ART conducts research for an environmental friendly, com-petitive agriculture. We combine ecology, economy and agricultural technology in an integrated research ap-proach and develop scientific-based decision support for farmers, government authorities and society.
The Institute of Evolutionary Biology and Environmental Studies of the University of Zurich performs cutting edge research and student training in the fields of ecology, evolution and environmental sciences.
Two Ph.D. student positions are available; one in the research group “Ecological Farming” at Agroscope and one at the institute of Evolutionary Biology and Environmental Studies of the University of Zurich.

Position
Soil microbes represent the unseen majority of life on Earth and are essential for the functioning of terrestrial ecosystems as they catalyse unique and indispensable transformations in the biogeochemical cycles of the biosphere. The significance of soil microbial diversity for the functioning of agricultural and natural ecosystems is still poorly understood and soil microbial communities can be considered as a black box. Unraveling what soil microbes are doing in this black box has been identified as one of the major research areas in science, comparable to the search for life on Mars. The significance of microbial diversity for the functioning of agro-ecosystems will be investigated in this project.

Key questions include:
1.      Is plant productivity and ecosystem sustainability enhanced by microbial diversity (PhD 1 and 2)?
2.      Are there differences in microbial diversity between different agro-ecosystems (PhD 2)?

PhD 1 focuses on the importance of microbial diversity for ecosystem functioning. Experiments are performed under controlled conditions in the greenhouse using already established advanced microcosms with experimen-tal grassland communities. The second PhD characterizes microbial communities in a wide range of field sites using state of the art pyrosequencing techniques. This work will be followed by experiments with experimental plant communities and investigating the role of specific groups of soil microbes.

Selected References:
Petermann et al. 2008, Ecology 89: 2399-2406.
van der Heijden et al. 1998, Nature: 396, 72-75.
van der Heijden et al. 2008, Ecology Letters: 11: 296-310.
Verbruggen et al. 2010, New Phytologist 186: 968-979.
Wagg et al. 2011, Ecology Letters (in press, published on line)

Requirements
We seek enthusiastic students with a Masters in ecology, microbial ecology, soil ecology, molecular ecology or agronomy. For PhD1 experience in soil-, microbial- or plant community ecology is an advantage. For PhD 2, use of molecular biology tools (e.g. pyrosequencing and bio-informatics) is an advantage. Scientific work will be performed in a team consisting of experts from various disciplines (major supervisors are Prof. Bernhard Schmid, University of Zurich and Prof. Marcel van der Heijden, ART). Excellent knowledge of spoken and written English is required. We offer the opportunity to work in a young, multidisciplinary research team addressing a variety of topics in agronomy, ecology and environmental biology. Well equipped state-of-the-art analytical, microbiological, and molecular biology laboratories as well as climate chambers, greenhouses and experimental fields are available.

Conditions
The duration of the positions are three years. The salary is according to the guidelines of the Swiss National Science Foundation. The working place will be at the Institute of Environmental Biology and Environmental Sciences at the University of Zurich (see http://www.ieu.uzh.ch/index.html) (PhD 1) and at the Swiss Federal  Research Station Agroscope ART at Zurich-Affoltern, Switzerland (PhD 2).
The projects will start in Autumn/Winter 2011/2012.

Application
Deadline for application: 31 August 2011.
Please mention the keyword “PRODOCPhD” on your letter of application.
Applicants should submit a complete academic record, CV, certificates and a short description of research  interests to:
Agroscope Reckenholz-Tänikon ART, Fachgruppe Personal, Thomas Zehnder, Reckenholzstrasse 191,
8046 Zürich, Switzerland or e-mail to human_resources@art.admin.ch.

For further information please contact:
Prof. Dr. Marcel van der Heijden, Head of the Ecological Farming System Group, phone +41 44 377 72 78, or
e-mail: marcel.vanderheijden@art.admin.ch.(Do not send applications to this e-mail)

Biologie Humanmedizin Tiermedizin (Doktorarbeit / Diplomarbeit): Orphan nuclear receptors in the pathogenesis of fibrotic diseases

Tissue fibrosis can occur after defined events. However, in most cases, no initiating triggers will be identified. These idiopathic fibrotic diseases manifest on a single organ or as systemic diseases. The common and characteristic feature of these diseases is a pathologic activation of fibroblasts with increased release of collagen and other extracellular matrix proteins. The progressive accumulation of extracellular matrix destroys the physiological tissue architecture and impairs the function of the involved organs. Systemic sclerosis (SSc) may serve as a prototypical idiopathic fibrotic disease that affects the skin, lungs, heart, gastrointestinal tract and the kidneys. As in many other fibrotic diseases, failure of the affected organs is common and results in high morbidity and significantly increased mortality. A major reason for the poor prognosis of fibrotic diseases is the lack of effective anti-fibrotic therapies. Current treatment approaches are of limited efficacy
 and therapies specifically targeting the aberrant activation of fibroblasts and the release of extracellular matrix are not available for clinical use to date. This necessitates the development of novel targeted therapies to reduce fibrosis and tissue damage.

Orphan nuclear receptors are defined as a group of receptors that can translocate into the nucleus and for which no physiologic ligand has been identified to date. Most of these orphan nuclear receptors function as transcriptional regulators either by direct binding to the promoters of target genes or by modulating the transcriptional activity of other transcription factors. We could demonstrate recently that several orphan nuclear receptors play key-roles in the pathogenesis of fibrotic diseases. By fine-tuning major pro-fibrotic pathways such as TGF&#946;- and PDGF signalling, nuclear factors are crucial mediators of fibroblast activation in fibrotic diseases. We could also demonstrate that targeting of nuclear receptors might be a promising therapeutic approach in fibrotic diseases.
We now aim to follow these findings and investigate the roles of other orphan nuclear receptors and their coreceptors. We will characterize the molecular mechanisms, by which these nuclear receptors regulate fibroblast activation in vitro and evaluate their potential as novel therapeutic targets in different mouse models.

Methoden:
The work includes standard techniques such as real-time PCR, PCR, siRNA, reporter assays, cloning, transfection, nucleofection, Western blot, FACS, ELISA, EMSAs, Chip assays, histology, immunhistochemistry, immunofluorescence, work with different animal models and adenoviral infections. Generation of conditional knockout mice and fibroblast specific knockout are also planned.

Anfangsdatum: 15. Oktober 2011

geschätzte Dauer: 36 months

Bezahlung: Standard

Veröffentlichungen:
Publications from 2010 and 2011:

1.      Avouac J, Cagnard N, Distler JH, Schoindre Y, Ruiz B, Couraud PO, Uzan G, Boileau C, Chiocchia G, Allanore Y. Insights into the pathogenesis of systemic sclerosis based on gene expression profile of progenitor-derived endothelial cells. Arthritis Rheum. 2011 Jul 18.
2.      Allanore Y, Saad M, Dieudé P, Avouac J, Distler JH, Amouyel P, Matucci-Cerinic M, Riemekasten G, Airo P, Melchers I, Hachulla E, Cusi D, Wichmann HE, Wipff J, Lambert JC, Hunzelmann N, Tiev K, Caramaschi P, Diot E, Kowal-Bielecka O, Valentini G, Mouthon L, Czirják L, Damjanov N, Salvi E, Conti C, Müller M, Müller-Ladner U, Riccieri V, Ruiz B, Cracowski JL, Letenneur L, Dupuy AM, Meyer O, Kahan A, Munnich A, Boileau C, Martinez M. Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis. PLoS Genet. 2011 Jul;7(7):e1002091. Epub 2011 Jul 7.
3.      Kollias G, Papadaki P, Apparailly F, Vervoordeldonk MJ, Holmdahl R, Baumans V, Desaintes C, Di Santo J, Distler J, Garside P, Hegen M, Huizinga TW, Jüngel A, Klareskog L, McInnes I, Ragoussis I, Schett G, Hart BT, Tak PP, Toes R, van den Berg W, Wurst W, Gay S. Animal models for arthritis: innovative tools for prevention and treatment. Ann Rheum Dis. 2011 May 30.
4.      Distler JH, Strapatsas T, Huscher D, Dees C, Akhmetshina A, Kiener HP, Tarner IH, Maurer B, Walder M, Michel B, Gay S, Smolen JS, Müller-Ladner U, Schett G, Distler O. Dysbalance of angiogenic and angiostatic mediators in patients with mixed connective tissue disease. Ann Rheum Dis. 2011 Jul;70(7):1197-202.
5.      Dees C, Akhmetshina A, Zerr P, Reich N, Palumbo K, Horn A, Jüngel A, Beyer C, Krönke G, Zwerina J, Reiter R, Alenina N, Maroteaux L, Gay S, Schett G, Distler O, Distler JH. Platelet-derived serotonin links vascular disease and tissue fibrosis. J Exp Med April 25, 2011
6.      Beyer C, Axmann R, Sahinbegovic E, Distler JH, Manger B, Schett G, Zwerina J. Anti-interleukin 6 receptor therapy as rescue treatment for giant cell arteritis. Ann Rheum Dis. 2011 Apr 24.
7.      Palumbo K, Zerr P, Tomcik M, Vollath S, Dees C, Akhmetshina A, Avouac J, Yaniv M, Distler O, Schett G, Distler JH. The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis. Ann Rheum Dis. 2011 Apr 24.
8.      Kireva T, Erhardt A, Tiegs G, Tilg H, Denk H, Haybaeck J, Aigner E, Moschen A, Distler JH, Schett G, Zwerina J. Transcription factor Fra-1 induces cholangitis and liver fibrosis. Hepatology. 2011 Apr;53(4):1287-97.
9.      Avouac J, Clemessy M, Distler JH, Gasc JM, Ruiz B, Vacher-Lavenu MC, Wipff J, Kahan A, Boileau C, Corvol P, Allanore Y. Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis: potential contribution to perturbed angiogenesis and fibrosis. Rheumatology (Oxford). 2011 Mar 30.
10.     Dees C, Tomcik M, Zerr P, Akhmetshina A, Horn A, Palumbo K, Beyer C, Zwerina J, Distler O, Schett G, Distler JH. Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis. Ann Rheum Dis. 2011 Mar 30.
11.     Distler JH, Akhmetshina A, Dees C, Jüngel A, Stürzl M, Gay S, Pisetsky DS, Schett G, Distler O. Induction of apoptosis in circulating angiogenic cells by microparticles. Arthritis Rheum. 2011 Mar 24.
12.     Zwerina K, Baum W, Axmann R, Ruiz Heiland G, Distler JH, Smolen J, Hayer S, Zwerina J, Schett G. Vitamin D receptor regulates TNF-mediated arthritis. Ann Rheum Dis. 2011 Mar 17.
13.     Klinger P, Surmann-Schmitt C, Brem M, Swoboda B, Distler J, Carl HD, von der Mark K, Hennig FF, Gelse K. Chondromodulin-I stabilizes the chondrocyte phenotype and inhibits endochondral ossification of cartilage repair tissue. Arthritis Rheum. 2011 Mar 9.
14.     Guiducci S, Ricci L, Romano E, Ceccarelli C, Distler JH, Miniati I, Calabri GB, Distler O, Matucci Cerinic M, Falcini F. Microparticles and Kawasaki disease: a marker of vascular damage? Clin Exp Rheumatol. 2011 Feb 17.
15.     Dees C, Zerr P, Tomcik M, Beyer C, Horn A, Akhmetshina A, Palumbo K, Reich N, Zwerina J, Sticherling M, Mattson MP, Distler O, Schett G, Distler JH. Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum. 2011 Feb 10.
16.     Beyer C, Distler JH, Allanore Y, Aringer M, Avouac J, Czirják L, Cutolo M, Damjanov N, Del Galdo F, Fligelstone K, Guiducci S, Kowal-Bielecka O, van Laar JM, Martucci-Cerinic M, Müller-Ladner U, Riemekasten G, Tarner IH, Tyndall A, Kennedy AT, Valentini G, Vettori S, Walker UA, Denton C, Distler O; ; the EUSTAR Biobanking Group. EUSTAR biobanking: recommendations for the collection, storage and distribution of biospecimens in scleroderma research. Ann Rheum Dis. 2011 Feb 1.
17.     Rugien&#279; R, Dadonien&#279; J, Aleknavi&#269;ius E, Tikuišis R, Distler J, Schett G, Venalis P, Venalis A. Prevalence of paraneoplastic rheumatic syndromes and their antibody profile among patients with solid tumours. Clin Rheumatol. 2011 Jan 12.
18.     Balistreri E, Garcia-Gonzalez E, Selvi E, Akhmetshina A, Palumbo K, Lorenzini S, Maggio R, Lucatelli M, Galeazzi M, Distler J. The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model. Ann Rheum Dis. 2010 Dec 21.
19.     Dieudé P, Guedj M, Truchetet ME, Wipff J, Revillod L, Riemekasten G, Matucci-Cerinic M, Melchers I, Hachulla E, Airo P, Diot E, Hunzelmann N, Mouthon L, Cabane J, Cracowski JL, Riccieri V, Distler J, Amoura Z, Valentini G, Camaraschi P, Tarner I, Frances C, Carpentier P, Brembilla NC, Meyer O, Kahan A, Chizzolini C, Boileau C, Allanore Y. Association of the CD226 307Ser variant with systemic sclerosis: Evidence for a contribution of co-stimulation pathways in SSc pathogenesis. Arthritis Rheum. 2010 Dec 15.
20.     Dieudé P, Guedj M, Wipff J, Ruiz B, Riemekasten G, Airo P, Melchers I, Hachulla E, Cerinic MM, Diot E, Hunzelmann N, Caramaschi P, Sibilia J, Tiev K, Mouthon L, Riccieri V, Cracowski JL, Carpentier PH, Distler JH, Amoura Z, Tarner I, Avouac J, Meyer O, Kahan A, Boileau C, Allanore Y. NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis. Ann Rheum Dis. 2010 Dec 13.
21.     Polzer K, Neubert K, Meister S, Frey B, Baum W, Distler JH, Gückel E, Schett G, Voll RE, Zwerina J. Proteasome inhibition aggravates TNF-mediated bone resorption. Arthritis Rheum. 2010 Dec 6.
22.     Avouac J, Fürnrohr BG, Tomcik M, Palumbo K, Zerr P, Horn A, Dees C, Akhmetshina A, Beyer C, Distler O, Schett G, Allanore Y, Distler JH. Inactivation of the transcription factor STAT4 prevents inflammation-driven fibrosis in systemic sclerosis animal models. Arthritis Rheum. 2010 Nov 30.
23.     Heiland GR, Zwerina K, Baum W, Kireva T, Distler JH, Grisanti M, Asuncion F, Li X, Ominsky M, Richards W, Schett G, Zwerina J. Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression. Ann Rheum Dis. 2010 Sep 21.
24.     Weber CK, Haslbeck M, Englbrecht M, Sehnert B, Mielenz D, Graef D, Distler JH, Mueller RB, Burkhardt H, Schett G, Voll RE, Fürnrohr BG. Antibodies to the endoplasmic reticulum-resident chaperones calnexin, BiP and Grp94 in patients with rheumatoid arthritis and systemic lupus erythematosus. Rheumatology (Oxford). 2010 Aug 17.
25.     Dallos T, Heiland GR, Strehl J, Karonitsch T, Gross W, Moosig F, Holl-Ulrich C, Distler JH, Manger B, Schett G, Zwerina J. Chemokine CCL17/TARC in Churg-Strauss syndrome. Arthritis Rheum. 2010 Jul 28.
26.     Beyer C, Schett G, Distler O, Distler JH. Animal Models of Systemic Sclerosis: Prospects and Limitations. Arthritis Rheum. 2010 Jul 8. [Epub ahead of print].
27.     Marquart S, Zerr P, Akhmetshina A, Palumbo K, Reich N, Tomcik M, Horn A, Dees C, Engel M, Zwerina J, Distler O, Schett G, Distler JH. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis Rheum. 2010 Jul 8. [Epub ahead of print].
28.     Horn A, Distler JH. Vascular alterations upon activation of TGFbeta signaling in fibroblasts - implications for systemic sclerosis. Arthritis Res Ther. 2010 Jun 18;12(3):125. [Epub ahead of print].
29.     Distler JH, Distler O. Inflammation: Microparticles and their roles in inflammatory arthritides. Nat Rev Rheumatol. 2010 Jul;6(7):385-6.
30.     Wipff J, Dieudé P, Guedj M, Ruiz B, Riemekasten G, Cracowski J, Matucci-Cerinic M, Melchers I, Humbert M, Hachulla E, Airo P, Diot E, Hunzelmann N, Caramaschi P, Sibilia J, Valentini G, Tiev K, Girerd B, Mouthon L, Riccieri V, Carpentier P, Distler J, Amoura Z, Tarner I, Degano B, Avouac J, Meyer O, Kahan A, Boileau C, Allanore Y. Association of KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian population. Arthritis Rheum. 2010 Jun 15. [Epub ahead of print].
31.     Avouac J, Walker U, Tyndall A, Kahan A, Matucci-Cerinic M, Allanore Y; EUSTAR, Miniati I, Muller A, Iannone F, Distler O, Becvar R, Sierakowsky S, Kowal-Bielecka O, Coelho P, Cabane J, Cutolo M, Shoenfeld Y, Valentini G, Rovensky J, Riemekasten G, Vlachoyiannopoulos P, Caporali R, Jiri S, Inanc M, Zimmermann Gorska I, Carreira P, Novak S, Czirjak L, Oliveira Ramos F, Jendro M, Chizzolini C, Kucharz EJ, Richter J, Cozzi F, Rozman B, Mallia CM, Gabrielli A, Farge D, Kiener HP, Schöffel D, Airo P, Wollheim F, Martinovic D, Trotta F, Jablonska S, Reich K, Bombardieri S, Siakka P, Pellerito R, Bambara LM, Morovic-Vergles J, Denton C, Hinrichs R, Van den Hoogen F, Damjanov N, Kötter I, Ortiz V, Heitmann S, Krasowska D, Seidel M, Hasler P, Van Laar JM, Kaltwasser JP, Foeldvari I, Juan Mas A, Bajocchi G, Wislowska M, Pereira Da Silva JA, Jacobsen S, Worm M, Graniger W, Kuhn A, Stankovic A, Cossutta R, Majdan M, Damjanovska Rajcevska L, Tikly M, Nasonov EL, Steinbrink K, Herrick A
 , Müller-Ladner U, Dinc A, Scorza R, Sondergaard K, Indiveri F, Nielsen H, Szekanecz Z, Silver RM, Antivalle M, Espinosa IB, García de la Pena Lefebvre P, Midtvedt O, Launay D, Valesini F, Tuvik P, Ionescu RM, Del Papa N, Pinto S, Wigley F, Mihai C, Sinziana Capranu M, Sunderkötter C, Jun JB, Alhasani S, Distler JH, Ton E, Soukup T, Seibold J, Zeni S, Nash P, Mouthon L, De Keyser F, Duruöz MT, Cantatore FP, Strauss G, von Mülhen CA, Pozzi MR, Eyerich K, Szechinski J, Keiserman M, Houssiau FA, Román-Ivorra JA, Krummel-Lorenz B, Aringer M, Westhovens R, Bellisai F, Mayer M, Stoeckl F, Uprus M, Volpe A, Buslau M, Yavuz S, Granel B, Valderílio Feijó A, Del Galdo F, Popa S, Zenone T, Ricardo Machado X, Pileckyte M, Stebbings S, Mathieu A, Tulli A, Tourinho T, Souza R, Acayaba de Toledo R, Stamp L, Solanki K, Veale D, Francisco Marques Neto J, Bagnato GF, Loyo E, Toloza S, Li M, Ahmed Abdel Atty Mohamed W, Cobankara V, Olas J, Salsano F, Oksel F, Tanaseanu CM, Foti R, Ancuta C, Vo
 nk M, Caramashi P, Beretta L, Balbir A, Chiàla A, Pasalic Simic K,
io M, Stamenkovic B, Rednic S, Host N, Pellerito R, Hachulla E, Furst DE. Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database. J Rheumatol. 2010 Jul;37(7):1488-501. Epub 2010 Jun 15.
32.     Dieudé P, Guedj M, Wipff J, Ruiz B, Riemekasten G, Matucci-Cerinic M, Melchers I, Hachulla E, Airo P, Diot E, Hunzelmann N, Cabane J, Mouthon L, Cracowski JL, Riccieri V, Distler J, Meyer O, Kahan A, Boileau C, Allanore Y. Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population. Ann Rheum Dis. 2010 May 28. [Epub ahead of print].
33.     Krönke G, Uderhardt S, Kim KA, Stock M, Scholtysek C, Zaiss MM, Surmann-Schmitt C, Luther J, Katzenbeisser J, David JP, Abdollahi-Roodsaz S, Tran K, Bright JM, Binnerts ME, Akhmetshina A, Böhm C, Distler JH, Joosten LA, Schett G, Abo A. R-spondin1 protects against inflammatory bone damage during murine arthritis by modulating the wnt pathway. Arthritis Rheum. 2010 Apr 6. [Epub ahead of print].
34.     Beyer C, Distler JH, Distler O. Are tyrosine kinase inhibitors promising for the treatment of systemic sclerosis and other fibrotic diseases? Swiss Med Wkly. 2010 Apr 26. [Epub ahead of print].
35.     Reich N, Beyer C, Gelse K, Akhmetshina A, Dees C, Zwerina J, Schett G, Distler O, Distler JH. Microparticles stimulate angiogenesis by inducing ELR(+) CXC-chemokines in synovial fibroblasts. J Cell Mol Med. 2010 Mar 8. [Epub ahead of print].
36.     Maurer B, Stanczyk J, Jüngel A, Akhmetshina A, Trenkmann M, Brock M, Kowal-Bielecka O, Gay RE, Michel BA, Distler JH, Gay S, Distler O. miR-29 is a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum. 2010 Mar 3. [Epub ahead of print].
37.     Akhmetshina A, Beer J, Polzer K, Englbrecht M, Palumbo K, Dees C, Reich N, Zwerina J, Szucs G, Gusinde J, Nevskaya T, Distler O, Kerjaschki D, Schett G, Distler JH. Decreased lymphatic vessel counts in systemic sclerosis - Association with fingertip ulcers. Arthritis Rheum. 2010 Feb 12. [Epub ahead of print].
38.     Reich N, Maurer B, Akhmetshina A, Venalis P, Dees C, Zwerina J, Nevskaja T,  Schett G, Distler JH. The transcription factor fos-related antigen-2 (Fra-2) regulates the production of extracellular matrix in systemic sclerosis. Arthritis Rheum 2010 Jan;62(1):280-90.
39.     Distler JH and Distler O. Tyrosine kinase inhibitors for the treatment of fibrotic diseases such as systemic sclerosis: towards molecular targeted therapies. Ann Rheum Dis. 2010 Jan;69 Suppl 1:i48-51.
40.     Functional autoantibodies against serpin E2 in rheumatoid arthritis. Maciejewska-Rodrigues H, Al-Shamisi M, Hemmatazad H, Ospelt C, Bouton MC, Jäger D, Cope AP, Charles P, Plant D, Distler JH, Gay RE, Michel BA, Knuth A, Neidhart M, Gay S, Jüngel A.. Arthritis Rheum. 2010 Jan;62(1):93-104.

Postdoc: Plant Population Genomics (Stuttgart),University of Hohenheim,Germany

We invite applications for the position of a

POSTDOCTORAL SCIENTIST

to work on a project within the DFG-funded German Priority Program
“Adaptomics - Evolutionary Plant Solutions to Ecological
Challenges”. The project involves the population genomic analysis of
the two endemic plant species Arabidopsis pedemontana and Arabidopsis
cebennensis to study the relationship between genetic diversity,
reproductive system and natural selection in species with small
distribution ranges and small effective population
sizes. Investigating the interplay of genetic drift and natural
selection in response to environmental change will be a central focus
of the work and will be done by genome resequencing, genetic mapping,
and additional methods. The project will be carried out in close
collaboration with the group of Marcus Koch (University of Heidelberg)
and other partners in the program.

Highly motivated candidates with a Ph. D. degree, a background in
botany, population genetics, evolutionary biology or bioinformatics,
and a record of scientific publications are welcome to apply. The
ideal candidate has experience with population genetic simulations and
statistical analysis, scripting skills (e.g., R or Python) and a good
knowledge of modern genomics methods. The project requires team
working skills and the ability to coordinate and conduct field work in
the Piemontese Alps (Italy) and the Cevennes (France) together with
local botanists.

The successful applicant will be appointed for three years. The salary
will be according to the German government salary scale (TV-L E13) and
depends on previous experience, age and marital status. The University
of Hohenheim is an equal opportunity employer. Women and members of
minority groups are strongly encouraged to apply.

We are located on a beautiful campus in the South German city of
Stuttgart with a rich cultural life and a nice surrounding. There is a
critical mass of researchers in Hohenheim wo work on plant population
and quantitative genetic analysis (mostly in a plant breeding context)
for interaction and collaboration. Further information about our group
can be obtained from http://evoplant.uni-hohenheim.de or the address
below.

Please send your application (Cover letter, CV, list of publications,
letter of research interests, addresses of at least two references)
until 15 September 2011 as a single PDF document with the subject line
“Adaptomics” by email to Bärbel Hessenauer
(baerbel.hessenauer@uni-hohenheim.de).

Dr. Karl Schmid
Professor of Crop Biodiversity and Breeding
Informatics
Institute of Plant Breeding, Seed Science and Population
Genetics
Fruwirthstrasse 21
D-70599 Stuttgart, Germany
Phone: +49 711 459 23487
Email: karl.schmid@uni-hohenheim.de

Doktorand zum Thema H. pylori Infection Biology and Signal Transduction (Magdeburg)

Helicobacter pylori, the etiological agent of several human gastric diseases, induce the transcription factor NF-kB in colonized epithelial cells leading to the release of pro-inflammatory mediators.
The project is based on recent discoveries of novel signaling components of the NF-kB signaling pathway in mammalian cells. The successful applicants will define the role of this novel signaling molecules in Helicobacter pylori infection model by integrating molecularbiological, physiological and cell biological analysis.
The research program of the institute encompasses scientific projects on the regulation of the NF-kB signal transduction in the pathophysiology of inflammation and tumor biology (e.g. differentiation and cell cycle control). Here, the molecular and cell biological mechanisms of the intracellular signal transmission are of special interest. The institute allows an internationally competitive research by providing state of the art technologies in protein analysis, mass spectrometry and microscopy.
The institute coordinates and participates in a variety of coordinated programs funded by the German Research Foundation (GRK1167, SFB854, SFB779, SPP1365 and FOR521), the Federal Ministry of Education and Research (SysTec) and the European Union (Marie Curie Research Training Network).
Further, the institute is member of the interdisciplinary \"Research Center Dynamic Systems: Biosystems Engineering (CDS)\" funded by the Federal State of Saxony-Anhalt within the \"Excellence Program\" and the \"Magdeburg Center of Systems Biology (MaCS)\" funded by the Federal Ministry of Education and Research within the „FORSYS“ program \"Research Units in Systems Biology\".
The Otto von Guericke University wishes to increase the proportion of female academic personnel. Women are therefore explicitly encouraged to apply. Handicapped persons with equivalent qualification will be given preference.
Please send a motivation letter, CV and two references as PDF-file to Prof. Dr. M. Naumann (naumann@med.ovgu.de) until the end of April 2011.
For further information please, contact:
Dr. Olga Sokolova (olga.sokolova@med.ovgu.de)
Dr. Gunter Maubach (gunter.maubach@med.ovgu.de).
----------------------------------------------------------------------

PhD Position / Scientific Employee (Ulm, Germany)

The Institute of Embedded Systems/Real-Time Systems at Ulm University
invites applications for a 2-year full-time

                PhD Position / Scientific Employee

starting at October 1st, 2011 (including the option of a
prolongation).

Description:
The successful candidate shall continue the outstanding previous work
in the area of code generation for safety-critical real-time systems.
When designing software for embedded real-time systems, the Worst-Case
Execution Time (WCET) of a program plays an important role.
Unfortunately, today’s compilers are unable to consider the impact of
code optimizations on the resulting WCETs. The successful applicant’s
research activities will concentrate on designing novel compiler
optimizations in order to reduce WCETs. These optimizations will be
realized in the context of the WCET-aware C Compiler (WCC) and will be
scientifically examined using this compiler framework. The WCC
compiler is worldwide leading in the area of code generation and
optimization for safety-critical real-time systems. Many of WCC’s
WCET-oriented optimizations have been published in highly selective
journals and conferences from the embedded systems domain. The
successful candidate will have the opportunity to attain a PhD degree.
Teaching obligations of 4 hours per week belong to the successful
applicant’s duties.

Requirements:
Excellent diploma or master degree in computer science or a close-by
discipline, conferred by a university or a comparable institution.
Very good skills from the embedded systems domain are expected.
Knowledge in the areas of WCET analysis or compiler construction is
appreciated but is not key requirement for the vacant position. The
successful applicant should have very good communication (English
and/or German) and programming skills (C++).

A salary according to the German labor contract TV-L will be paid.

Interested candidates are asked to submit an application containing
the usual documentation by September 18th, 2011 to

                         Dr. Heiko Falk
         Institut für Eingebettete Systeme/Echtzeitsysteme
                         Universität Ulm
                            89069 Ulm
                 e-mail: Heiko.Falk@uni-ulm.de

The University of Ulm is committed to increase the share of women in
research and teaching positions and therefore explicitly encourages
female candidates to apply.

Physically disabled applicants receive favorable consideration when
equally qualified. The appointment is made by the central university
administration.

PhD student is sought to work in the framework of a BOF funded project in the domain of toxicometallomics, Universiteit Hasselt (Sonstige)

A motivated PhD student is sought to work in the framework of a BOF funded project in the domain of toxicometallomics. The project aims to develop analytical strategies and analytical methods for the determination of the concentration of heavy metals and metalloids including element speciation in biological fluids (blood samples). To reach this aim in first order ICP/MS and hyphenated techniques will be used on a great number of samples. Results will be correlated with data on the molecular level (outcome of another PhD student) to study the mechanism and relationships with fine dust and their role on health effects.

Profile and Qualification/diploma
The candidate is expected to perform research in the area of analytical chemistry. Candidates will have a master degree in chemistry, biochemistry, bio-engineer or an equivalent diploma. A good command of the English language and willingness to perform research in team-oriented research is required. Experience in ICP/MS and hyphenated techniques is recommended.

Additional information
Prof. dr. T. Nawrot (+32-11-26 83 82, tim.nawrot@uhasselt.be)
Prof. dr. R. Carleer (+32-11-26 83 85, robert.carleer@uhasselt.be)
Prof. dr. J. Yperman (+32-11-26 83 20, jan.yperman@uhasselt.be)

Information about selection procedure and labour conditions:
Mister Yves SOEN, +32-11-268085, yves.soen@uhasselt.be

Candidate nomination:
via solicitation forms which can be downloaded:
http://www.uhasselt.be/download/AAP-UH.doc and sent via e-mail to: jobs@uhasselt.be.
end date of submission: 19 August 2011.

PhD student - microbial ecology - inflammatory bowel diseases, Technische Universität München,Germany

The Chair for Biofunctionality of Food at the Technische Universität München is looking for

1 PhD student
(TV-L13/II, Tarifgebiet west)

The position is available immediately and for a duration of 3 years.
Research activities at the Chair for Biofunctionality of Food are focused on the role of intestinal microorganisms and nutrition on the development and regulation of chronic inflammatory diseases.
We offer an exciting research project, well-equipped laboratories and a fruitful scientific atmosphere.
We are looking for a highly motivated PhD student, who will be part of the Young Research Group “Intestinal Microbiome” aiming at characterizing the role of intestinal microorganisms in health and diseases. The project will be focused on the characterization of microbial triggers (e.g. heat shock proteins) in inflammatory bowel diseases at the level of single molecules/strains and the entire ecosystem. Expertise in any of the following areas will be a plus: molecular & classical microbiology, immunology, microbial ecology, bioinformatics.

For further information or to send an application (cover letter + CV), please contact:

Dr. Thomas Clavel
TUM, BFLM, Gregor-Mendel-Str. 2, 85350 Freising-Weihenstephan
thomas.clavel@wzw.tum.de
Phone: +49 (0)81 61 71 23 75

Scientific Coordinator (m/f),Friedrich Schiller University of Jena,Germany

The chair of hydrogeology at the institute of geosciences of the Friedrich Schiller University of Jena seeks for a

scientific coordinator (m/f)

of the priority programme SPP 1315 “Biogeochemical Interfaces in Soil” (www.spp1315.uni-jena.de) funded by the German Research Foundation (DFG). The priority programme comprises 20 individual research projects across Germany and Austria covering interdisciplinary (chemical, physical, microbiological) studies on the properties, formation and maturation of biogeochemical interfaces in soil and their determining role for the fate or organic chemicals.

It is a 100%, fixed-term position starting from 1.10.2011 for an initial two years. Salary is according the German tariff TV-L 13.

Responsibilities:
- Coordination of the research projects and thematic groups, of joint experiments and integrative analysis of the results
- Organization of (international) meetings: annual SPP colloquia, scientific symposia, sessions at conferences, final SPP conference 2014
- Preparation of progress reports and integrative scientific publications
- Administration of the web page

Requirements:
- PhD degree in a relevant discipline (e.g., soil science, geoscience disciplines)
- Fluency in German and English
- Experience in scientific publishing

The Friedrich Schiller University attempts to appoint more female scientists who are particularly encouraged to submit their application. Given equal qualification, applications from disabled persons will be considered preferentially.

Applications with the usual documents should be directed no later than 15.09.2011 to
Friedrich Schiller University of Jena
Institute of Geosciences
Chair of Hydrogeology
Prof. Dr. K.U. Totsche
Burgweg 11
07749 Jena, Germany

PostDoc/Scientist position in Computational Hydrology (m/f) (72074 Tübingen),Germany

Water & Earth System Science Competence Cluster (WESS)

WESS – the Water and Earth System Science Competence Cluster - was founded by the Universities of Tübingen, Hohenheim, and Stuttgart together with the Helmholtz-Centre for Environmental Research, UFZ, in 2009 in order to strengthen the research cooperation between these institutions and to facilitate interdisciplinary research in the fields of water and solute fluxes at the catchment scale as a function of climate and land use changes (www.wess.info).

WESS invites applications for a

PostDoc/Scientist position in “Computational Hydrology” (m/f)

to develop and apply simulation codes for coupled flow and reactive transport of carbon and nitrogen components at the land surface and in the shallow subsurface, contributing to the integrated modelling framework of WESS. The position offers an excellent environment for working with a highly skilled interdisciplinary team.

The successful candidate will work on the following research topics:
1.      Model development: Development of appropriate concepts for coupling water flow and reactive solute transport processes across the land surface, through the soil-plant system down to groundwater. The focus is on the interaction between vegetation and hydrological processes.
2.      Model implementation: WESS is aiming at establishing a flexible simulation framework for coupled hydrosystem analysis. The new modules will be coupled to existing simulations tools via efficient interfaces.
3.      Model application: The simulation framework will be applied to data sets from the WESS test sites in South-West (Neckar subcatchments) and East Germany (TERENO Bode observatory).

Applicants are expected to have:
&#61607;        A scientific background in quantitative geosciences, physics, applied mathematics, or civil and environmental engineering,
&#61607;        A PhD in a related field and an appropriate publication record
&#61607;        Skills in software development and scientific computation (high performance computing, code coupling and distributed development)
&#61607;        Very good written and oral communication skills in English

Further information can be provided by: Prof. Dr.-Ing. Olaf Kolditz (olaf.kolditz@ufz.de); Prof. Dr. Thilo Streck (thilo.streck@uni-hohenheim.de).

The appointment will be limited to June 2013 (subject to approval of funding; extension of contract is possible). The place of work is Tübingen/Leipzig, Germany. The candidate will spend about 20% of work time at the WESS partner institutes in order to foster the cooperation within WESS. Salary will be according to civil service guidelines (TVL E13/E14), depending on personal skills and work experiences. Women are explicitly encouraged to apply to increase their share in science and research. Physically handicapped persons will be favored if they are equally qualified.

Please send your complete application documents (curriculum vitae, certificates, description of scientific development and a list of publications) until 25.08.2011 under the code digit WESS W5.2 to WESS, c/o University of Tübingen, Dept. of Geoscience, Dr. Hermann Rügner, Hölderlinstrasse 12, 72074 Tübingen, Germany (h.ruegner@uni-tuebingen.de).

Senior scientist: Spatial vulnerability and risk assessment (f/m) ,Dresden,germany

Senior scientist: Spatial vulnerability and risk assessment (f/m)
The Institute
The Leibniz Institute of Ecological Urban and Regional Development (IOER) is member of the Leibniz Association and with its more than 130 employees the largest spatial planning science institute in Germany. It carries out interdisciplinary research into issues of sustainable urban and regional development from an ecological perspective across all spatial scales.
The position
Your overall task is to spatially assess the vulnerability and risk of cities and regions using GIS, statistical methods and other tools. Thematic areas are natural hazards and climate change. Research is dealing with the conceptual development and programming of vulnerability and risk assessment models on multiple spatial scales.
Your competences
A doctor’s degree in earth system sciences or comparable education with very good to excellent grade together with an expertise in geoinformatics is requested. Research experience should regard to GIS-based modelling with according programming techniques.
Application
For further information please refer to
http://www.ioer.de/aktuelles/stellenausschreibungen/

----------------------------------------------------------------

Von:

J. Förster
j.foerster@ioer.de
Leibniz-Institut für ökologische Raumentwicklung e.V.
Dresden

Ansprechpartner: A.Wendebaum, a.wendebaum@ioer.de

----------------------------------------------------------------

**********************************************************************
Sie erhalten diese Mail, da sie als Kumar Raja <webdhuniyablog@GMAIL.COM> in der Liste SCIENCE-JOBS-DE eingetragen sind. Um sich von dieser Liste abzumelden, schreiben Sie eine E-Mail an die Adresse SCIENCE-JOBS-DE-unsubscribe-request@listserv.uni-heidelberg.de . Betreff und Inhalt der Mail sind ohne Bedeutung.
You are receiving this mail, because you are subscribed as Kumar Raja <webdhuniyablog@GMAIL.COM> to the list SCIENCE-JOBS-DE. To unsubscribe from this list, send an e-mail to SCIENCE-JOBS-DE-unsubscribe-request@listserv.uni-heidelberg.de . Topic and contents of that mail are of no significance.

Mehr Informationen zu SCIENCE-JOBS-DE finden Sie im WWW unter der Adresse http://jobs.uni-hd.de insbesondere Informationen fuer Anbieter und "Netiquette".
More information on SCIENCE-JOBS-DE is available on the web at http://jobs.uni-hd.de regarding information for offerings and "netiquette".

Doctoral candidate: Scenario-based environmental planning for regional climate change adaptation (f/m) (Dresden)

Doctoral candidate: Scenario-based environmental planning for regional climate change adaptation (f/m)
The Institute
The Leibniz Institute of Ecological Urban and Regional Development (IOER) is member of the Leibniz Association and with its more than 130 employees the largest spatial planning science institute in Germany. It carries out interdisciplinary research into issues of sustainable urban and regional development from an ecological perspective across all spatial scales.
The position
You are preparing a doctoral thesis on scenario-based environmental planning for regional climate change adaptation. Main focus is the treatment of scenario and model uncertainties from climate change impact assessment in planning instruments for environmental protection or management of environmental risks.
Your competences
A master’s degree in geography with knowledge in physical and human aspects and planning issues or comparable education with very good to excellent grade is requested.
Application
For further information please refer to
http://www.ioer.de/aktuelles/stellenausschreibungen/

PhD Position in Department of Environmental Geoscience,University of Vienna,Austria

The Department of Environmental Geoscience is a highly motivated international group carrying research in hydrogeology, fate of inorganic/organic pollutants and nanogeoscience.

We currently have an exciting opportunity for a 4 year pre-doc research assistant with the possibility to complete a PhD degree. The 4 year-position includes:

   the support from senior researchers  to develop all the skills necessary to complete a PhD project, from the development of a research problematic up to the publication of the results

   excellent laboratory facilities + financial support for the research activities

   working in a motivating and international environment (working language is English) and being exposed to many valuable opportunities for career development (networking, conferences, teaching experience etc…)

   Annual salary of 25-30 000 € gross, including health/pension scheme

We are looking for applicants with a Diploma/Master in Earth Sciences, Environmental Sciences or Chemistry. The successful applicant will be willing to carry out research within the fields of our Department (please visit our webpage for further information) and to actively contribute to the tasks of the working group (e.g. teaching, responsibilities for lab instruments). He/She will be motivated, independent and reliable so that research goals can be achieved. Good writing/communication skills and analytical or modelling experience are appreciated.

Applications including a CV, a letter of motivation and a research statement (describing the possible topic and personal interes of research to be carried out in the Department) should be sent to sabine.kranzl@univie.ac.at or thilo.hofmann@univie.ac.at

For further information please visit our website and/or contact Kranzl, Sabine (sabine.kranzl@univie.ac.at).

The University of Vienna intends to increase the number of women on its faculty, particularly in high-level positions, and therefore specifically invites applications by women. Among equally qualified applicants women will receive preferential

Postdoctoral Researcher (Freshwater Ecologist) (Frankfurt am Main), Germany

Job Advertisement Ref. #04-11005

Senckenberg Gesellschaft für Naturforschung has an international reputation in all fields of Natural History research. It runs six research institutes and two museums in Germany and is also custodian of the UNESCO World Heritage Site at Messel.

The Senckenberg Research Institute, Department of Limnology and Conservation, Gelnhausen is looking for a:

Postdoctoral Researcher (Freshwater Ecologist)

The successful candidate will join a highly motivated team of 20 scientists and research support staff who are working at the Senckenberg Research Station Gelnhausen (close to Frankfurt) on a variety of topics in river and floodplain ecology and conservation.

Candidates must hold a PhD, have a strong track record of international publications, a background in freshwater (macro-) ecology and zoology, and advanced skills in analysis of large datasets and/or ecological modelling.

The successful candidate will be expected to develop an externally funded research programme, to manage projects, analyse large data sets, and to advise graduate students. We are seeking an individual with excellent verbal and written communication skills who is willing to co-operate with other research groups at Senckenberg, the University of Frankfurt, and the Biodiversity and Climate Research Centre (BiK-F).

The position is full time. Salary is based on Tarifvertrag Hessen TV-H E13. The position is available from October 1st. Initial employment is for up to two years with a possible extension being subject to personal performance and availability of funds.

Senckenberg wishes to increase the share of women in areas where they are underrepresented, and strongly encourages women to apply. Senckenberg has an affirmative action policy for the disabled and especially encourages them to apply.

Please apply by sending your application in a single pdf exclusively by e-mail, including a letter outlining your suitability for the post, a detailed CV, contact details of 2 referees, a list of publications and fundings until September 5, 2011 to: recruiting@senckenberg.de

Administrative Director
Dr. Johannes Heilmann
c/o Senckenberg Gesellschaft
für Naturforschung
Senckenberganlage 25
D-60325 Frankfurt/Main
E-mail: recruiting@senckenberg.de

For scientific enquiries feel free to contact: peter.haase@senckenberg.de

2 Doktorandenstellen im Rahmen einer überregionalen DFG-Forschergruppe (Kiel)

There are two openings for doctoral student positions within the framework of a nationwide DFG-Researchgroup entitled: “Mesenchymale und osteogene Signalwege in der Knochenmetastasierung (FOR 1586)”.
The open doctoral student positions are within the “SKELMET” TP4-project:
“Impact of inflammatory mechanisms on osteoblast-metastatic tumor cell interaction“

1 doctoral student (PhD), TV-L E13/65% for 3 years, starting August 2011

Employment of a PhD student (biologist, biochemist holding a Diploma/Master degree), who will perform in vitro studies concerning the role of cytokines, their inhibitors and TRAIL-receptors using several techniques such as cell culture, ELISA, immunostaining, Western blot, knock-down experiments, functional assays (invasion assays, migration assays, proliferation, osteoblast differentiation assay). The ambitious plans for the in vitro experiments require a highly motivated team member, who is able to communicate with the external cooperation partners. A background in molecular, cell biological, and biochemical methods is mandatory.

1 doctoral student (veterinary medicine or other), TV-L E13/65% for 3 years, starting August 2011

For the planning and carrying out the ambitious and complex animal experiments in this project, employment of a veterinarian or a PhD student, who is striving for a demanding doctoral thesis. Our lab has a long-standing history of successful integration of veterinarians in research projects facilitating complex in vivo model systems for the investigation of tumor progression and metastasis. To date, five doctoral theses in veterinary medicine have been successfully supervised. The applicant will directly cooperate with surgical fellows in the highly demanding orthotopic tumor inoculation as well as tumor resection techniques in continuation of the clinically adapted tumor model established in our laboratory. Moreover, the veterinarian or PhD student will also supervise animal care and perform the application of pharmacological substances in animals. Furthermore, she/he will perform and supervise and evaluate the in vivo molecular imaging analyses of living anaesthetized expe!
 rimental animals. The successful candidate will come with respective interests for sophisticated in vivo tumor models and also require basic experience with cell culture techniques and histological and microscopical methods including immunohistochemistry.

Post-Doctoral Position in Tumorimmunology (Bern, Switzerland)

Post-Doctoral Position

Tumor Immunology Laboratory, Medical Oncology, Departement of Clinical Research, University of Berne, Switzerland

The main focus of our research is the characterisation of the immune-surveillance of solid tumors and of lymphomas/leukemias in preclinical mouse models.The integration within the Institute for Medical Oncology allows a direct access to clinical samples.
We have an open Postdoc position in our lab. The focus of the project is to characterize the interaction of the immune system with the hematopoietic and the leukemia stem cell. The successful applicant is expected to have experience in basic immunology and molecular biology that is documented by a strong publication record in this field.

Please send your application, cv and publication list to:

Prof. A. Ochsenbein, Institute for Medical Oncology, Inselspital Bern, 3010 Berne, Switzerland, adrian.ochsenbein@insel.ch, Tel. +41 31 632 28442.

W1 Junior Professorship in Physical Oceanography (Hamburg)

The School of Mathematics, Informatics and Natural Sciences, Institute of Oceanography invites applications for a W1 Junior Professorship in Physical Oceanography starting as soon as possible (ref. no. JP172).

Applicants are expected to demonstrate research experience on an international level as well as a successful track record in procuring external project funding. The University places particular value on the quality of teaching. We therefore request applicants provide details of both their teaching experience and their future teaching objectives.

The University aims to increase the number of women in research and teaching and explicitly encourages women to apply. Equally qualified female applicants will receive preference in accordance with the Hamburg Higher Education Law.

Tasks and responsibilities:

The junior professor will be expected to research and teach in the area of ocean dynamics. We are looking for a candidate with experience in the general theory of ocean dynamics as well as in aspects of meso-, submeso- or small-scale turbulent mixing with respect to theory, numeric modeling or observation. The junior professor will thus thematically and methodolog-ically enhance the existing capacity of the Institute of Oceanography. The successful candi-date will be required to participate actively in planning and implementing research initiatives, for example the establishment of a new collaborative research center (SFB). He or she will also be expected to work within the excellence cluster CliSAP (Integrated Climate System Analysis and Prediction).

Candidates should demonstrate willingness and the ability to carry out interdisciplinary colla-boration within the Institute for Oceanography, with the Center for Earth System Research and Sustainability (CEN) and more generally with the KlimaCampus. Candidates should be prepared to teach on the bachelor’s and master’s programs in the marine and climate sciences.

Requirements:
Academic qualifications and further requirements as specified in §18 of the Hamburg Higher Education Law.
Severely disabled applicants will receive preference over equally qualified non-disabled ap-plicants.
For further information, please contact Prof. Dr. Carsten Eden (carsten.eden@zmaw.de).
Die Universität Hamburg ist zertifiziert.
audit familiengerechte hochschule

Applications should include a curriculum vitae, a list of publications, details of teaching expe-rience and proposals for future courses. The deadline for applications is Aug, 11th 2011. Please send applications, accompanied by the reference number JP 172, to:
Präsident der Universität Hamburg
Referat Organisation & Personalentwicklung
Ausschreibungsstelle
Moorweidenstr. 18
20148 Hamburg
Germany
or via email to: UniHHAusschreibungsstelle@verw.uni-hamburg.de.

member of academic staff (E 13 TV-L) in TU Dresden

The Biotechnology Centre (BIOTEC, www.biotec.tu-dresden.de) is
a unique interdisciplinary centre focussing on research and
teaching in molecular bioengineering. The technology platform of
the BIOTEC is a central tool for implementing efficient
technology transfer into current research projects. Within the
platform a new service on advanced microscopy related image
processing will be established. The position will be related to
the light microscopy facility that offers an inspiring
interdisciplinary working environment.
Available  from 04.10.2011 - 30.09.2014, we are looking for a

            member of academic staff (E 13 TV-L)

The position is subject to approval of the third-party funds.
The period of employment is governed by the Fixed Term Research
Contracts Act (Wissenschaftszeitvertragsgesetz - WissZeitVG).
Tasks: service oriented assistance in the microscopy facility of
the BIOTEC technology platform; support of facility users in
standard and complex image analysis e.g. quantification and
colocalisation tasks; development of user- and project specific
software tools as plugins in already available software
solutions; teaching of basic image processing concepts in
student courses; teaching of advanced methods for high end
users; collaboration with the other Imaging Facilities in
Dresden and beyond.
Requirements: master or diploma degree in computational science,
computational biology or related subjects; at least 3 years of
working experience preferably in a service oriented environment;
good knowledge of a high-level programming language, preferably
C/C++ or Java; good knowledge in Matlab programming; Statistical
background; experience with image processing tools and
toolboxes, e.g.: ImageJ, Fiji, Matlab, CellProfiler, Imaris,
Huygens, Volocity; experience in writing image processing
scripts, macros and plugins; ability to work in a team; good
communication skills in English language; experience in one or
more of the following fields would be advantageous: biological
imaging, pattern matching, machine learning, image or signal
processing and computer graphics.
For further information about the institute, see www.biotec.tu.-
dresden.de
Applications from women are particularly welcome. The same
applies to disabled people.
Applications should contain a CV, publication list, list of
three contacts for references and should be sent by August 16,
2011 (stamped arrival date) to the following address: TU
Dresden, BIOTEC, Katrin Grosser, Tatzberg 47/49, 01307 Dresden,
Germany or to email: katrin.grosser@biotec.tu-dresden.de (Please
note: We are currently not able to receive electronically signed
and encrypted data).

Laboratory Technician (Hamburg, Germanu)

The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organizations in the world. The Headquarters Laboratory is located in Heidelberg (Germany) and the outstations are in Grenoble (France), Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).

The EMBL Hamburg Outstation offers an international and stimulating environment for research in molecular structural biology. The molecular and biochemistry laboratory is used for diverse research projects in structural biology. The lab is equipped for protein production, purification, crystallization and functional analysis. The laboratory technician will work in the group of Matthias Wilmanns. The focus of the group is on large protein complexes from various cell types. At the molecular level there are particular interests into the regulation of protein kinases, the regulation of transcription factors, structural proteins in the muscle, receptors for protein translocation, and host/pathogen interactions. Main tasks of the research technician are:
• To be involved in day-to-day lab management, including purchasing, equipment maintenance, lab safety, basic training.
• To cooperate with other members of the institute, involved in overall laboratory management, including new facilities for protein production and characterization for external visitors.
• To actively contribute in ongoing research projects under the supervision of scientists that are members of the Wilmanns group.

Qualifications and Experience
Applicants should have a bachelor or master degree in a relevant field (biology or related disciplines). Working experience in molecular biology is essential. Previous experience with large scale protein expression and purification using ÄKTA systems will be considered advantageous. Project management experience, excellent communication skills and the ability to collaborate with other research teams is essential. Good knowledge of desktop software applications and fluency in English is mandatory, German language skills are desirable.

Please apply online through www.embl.org/jobs

PostDoc Position in the Molecular Biomechanics group (Heidelberg, Berlin, Shanghai) (Heidelberg, Germany)

PostDoc Position in the Molecular Biomechanics group at the Heidelberg Institute for Theoretical Studies (HITS) in Heidelberg, Germany

We are seeking a highly motivated candidate for a postdoc position in the field of computational molecular biomechanics. The project will involve the usage of novel molecular modeling and simulation techniques, for studying the interplay of biochemistry and mechanics in blood coagulation proteins. The successful candidate will be part of a prolific interdisciplinary research consortium funded by Deutsche Forschungsgemeinschaft (DFG), fostering a direct collaboration with experimentalists and clinicians.

Candidates should have a PhD degree in computational biophysics, chemistry or related fields. A broad expertise in Molecular Dynamics simulations or Molecular Modeling, preferably in both, is required, as evidenced by the applicant’s publication record and presentations at international conferences.

Directly involved are the Theory Department of the Fritz Haber Institute of the Max Planck Society (FHI-MPG, Carsten Baldauf, www.fhi-berlin.mpg.de/~baldauf) and the Molecular Biomechanics Group of the Heidelberg Institute for Theoretical Studies (HITS, Frauke Graeter, www.h-its.org/english/research/mbm/). Main working location will be HITS in Heidelberg, a non-profit research laboratory with a strong focus on computational biology. Research stays at FHI-MPG in Berlin or at PICB in Shanghai are possible and encouraged.

To apply, please send a short motivation letter, CV, list of publications, and contact details of three references by August 31 to:

Stefanie Szymorek
HITS gGmbH
HITS 02-2011
Schloss-Wolfsbrunnenweg 35
69118 Heidelberg
Germany
http://www.h-its.org
email: Stefanie.szymorek@h-its.org

Inquiries should be addressed to:
Carsten Baldauf (baldauf@fhi-berlin.mpg.de)
and
Frauke Graeter (frauke.graeter@h-its.org)

PhD student position in London (United Kingdom)

Have you recently obtained your Diploma in Medicine of Biology? Are your interested in neuroscience, human diseases and genetic model organisms like Drosophila melanogaster? Would you like to study for a PhD in a top University located right in the middle of London?

A PhD student position is available at the MRC Centre for Developmental Neurobiology (CDN) in the laboratory of Manolis Fanto to study cellular mechanisms of neurodegeneration in Drosophila.  Registration as MPhil/PhD with KCL graduate study program will be required within July 2012 and can be backdated by three Months.

The MRC-CDN is rated as one of the best neuroscience institutions in the UK and is located at the Guy’s Campus of King’s College London, next to London Bridge station.
The Fanto lab studies the mechanisms of neurodegeneration due to Atrophin and Fat with a number of advanced genetic and cellular approaches.
Charroux and Fanto, Autophagy 6 (5), 667 (2010).
Nisoli et al., Cell Death Differ 17 (10), 1577 (2010).
Napoletano et al., The EMBO journal 30 (5), 945-58 (2011).
Calamita and Fanto, Autophagy in press (2011).
Volpi et al., JoVE in press (2011).

I am looking for a highly motivated candidate, fluent in English, with a strong interest in genetics or neurobiology, willing to learn how to work independently on this project, whilst integrated into a larger group effort. Enthusiasm, determination, resilience and ability to work in a team are essential. For informal enquiries and application please contact Manolis Fanto (manolis.fanto@kcl.ac.uk) sending a copy of your academic cv.

Further information about the lab, the MRC-CDN and KCL can be found at the following websites.

http://www.mrcdevneuro.org/fanto/
http://www.kcl.ac.uk/depsta/biomedical/mrc/
http://www.fantolab.eu/

PhD Position (Bonn, Germany): Subsurface-Land Surface-Atmospheric Feedbacks under a range of land cover conditions (Bonn, Germany)

 The Meteorological Institute of the Rheinische Friedrich-Wilhelms-Universität Bonn, Germany,invites applications for

1 PhD Graduate Research Assistantship
In the framework of the Transregional Collaborative Research Center 32 (TR 32) on

“Subsurface-Land Surface-Atmospheric Feedbacks under a range of land cover conditions”

Students with interest in Hydrogeology, Hydrology, Atmospheric sciences, and Environmental Modeling are encouraged to apply. You will be working in a productive, multidisciplinary environment within the TR32 project. Prerequisites for the position are a Master degree in
Environmental Engineering, Meteorology, Geosciences, or similar field, and English writing.

Experience in open source code, Linux, and Parallel Processing is highly desirable. Programming skills in C, Fortran, and/or Matlab are an advantage.

This is a 3 year PhD position (starting on 1st January 2012 to 31st December 2014). Salary is 75% of Tvöd 13 level 1 (approximately 1300 Euro net salary per month).
Please send an application package (application letter detailing your interest in this position,training, and research interests; CV; certificates; and contact information of two references) as
a single pdf to Dr. Jehan Rihani (jehan.rihani@fulbrightmail.org).

1 PhD Position (cologne, Germany): Assimilation of remotely sensed data in the CLM for optimized modeling of photosynthesis (Bonn, Germany)

The Transregional Collaborative Research Center TR32 and the Institute of Geophysics and Meteorology at the University of Köln, Germany, invite applications for

1 PhD Graduate Research Assistantship

In the focus of the TR32, Patterns in Soil-Vegetation-Atmosphere Systems: Monitoring, Modeling, and Data, the following project is open:

Assimilation of remotely sensed data in the CLM for optimized modeling of photosynthesis.

We are seeking for a highly motivated Ph.D. student with strong interest and experience in the following fields:

-       quantitative modeling and computer programming
-       plant mediated exchange processes
-       hyperspectral remote sensing

The overall objective of the thesis is the improvement of the near-real-time modeling and prediction of plant mediated gas exchanges by the Community Land Model (CLM) for different plant functional types. The project focuses on the development of the models photosynthesis module. The candidate will develop algorithms and strategies for the assimilation of remotely sensed hyperspectral and thermal data sets and perform model source code modifications. The models sensitivity to different parameterization strategies will be studied. Based on fluorescence data provided by collaborating project sections improved simulated photosynthetic rates will be validated with actual photosynthesis.

Candidate with a M.Sc./Diplom in biology, plant ecophysiology, ecology, micrometeorology, environmental sciences or related disciplines are encouraged to apply. We expect a strong interest in process- and system-oriented research. Experience in computer programming (preferably FORTRAN, C) is required. Skills and strong interest in numerical modeling, model development and working with large data sets are beneficial.

The Ph.D. student will elaborate her/his dissertation within the TR32 at the University of Köln, Institute of Geophysics and Meteorology. For more information, you are kindly invited to visit our website www.tr32.de. The PhD's graduate research assistantship is for a 3 years period and is remunerated with a 75%-TV-L E13 Position.  Interested candidates should send a complete application package (CV; cover letter describing background, training and research interests; certificates; contact information of two references) as a single PDF to (Dr. Hella Ahrends, tr32@uni-bonn.de) The position is expected to commence January, 2011. Review of applications will begin immediately and continue until the position has been filled.

Equal employment opportunity: Selection for these positions will be based solely on merit without regard to gender, religion, national origin, political affiliation, marital or family status or other differences. Among equally qualified candidates, handicapped candidates will be given preference.

PhD in "Lasing Networks in Semiconductors" (Berlin),Germany

A new PhD position on "Lasing Networks in Semiconductors" (Experiment)
will be available at the Humboldt University of Berlin, Department of
Physics, Photonics Group (Prof. Fritz Henneberger). It is part of the
recently established International Research Training Group "Dynamical
Phenomena in Complex Networks: Fundamentals and Applications", wich is
expected to start October 2011. Admission to the PhD program requires a
Master or a Diploma degree, or their equivalent. The candidate is
expected to have broad interests and a solid background in nonlinear
physics, in particular in the fields of semiconductors and lasers.
She/he will perform experimental work in close interaction with the
theoretical partner in Brasil.  Active contributions to the overall
collaboration within  the framework of the training group are expected.

Short information on the project is found on
http://photonik.physik.hu-berlin.de/ede/irtg/p02.html
To express the intention to apply, and for informal inquiries about
the project and application procedure, please, contact
Dr. Hans-Jürgen Wünsche (http://photonik.physik.hu-berlin.de/ede).

PostDoc Mouse and Rat Behaviour Analysis - Berlin (Berlin),Germany

We are seeking a person to collaborate in leading and coordinating
research projects of behavioural analysis of neurological and
psychiatric dysfunction in mice. This will take place at the newly
established behaviour analysis core facility of the NeuroCure Center
of Excellence at the Charité - Universitätsmedizin, Humboldt
University and Free University, Berlin, Germany (www.neurocure.de).
The center provides behaviour analysis expertise and service for the
basic research and translational medicine projects conducted by the
NeuroCure PI research groups. It also persues the mission to become a
leader in the development of novel, state-of-the-art and
high-throughput methods for automated behaviour analysis in animal
models for translational medicine. To achieve this goal, the center’s
staff includes experts from biology, computer science and informatics,
electrical engineering and mechanical engineering and has access to
excellent workshop facilities. The center has been newly equipped with
state-of-the-art instruments and software for all the relevant
behaviour paradigms, installed in about 15 observation rooms. The
successful candidate should have solid experience in behavioural work
with mice and/or rats, a good publication record, experience in
securing outside funding and the ability to work collaboratively in
scientific discovery. As an additional qualification a strong
background in one of the following areas is expected: statistics,
computer programming or in vivo physiological methods. The position
with TV-L 13 salary can be filled immediately, appointment is
initially until Oct. 31, 2012 with the option for extension of further
5 years. Application evaluation will begin August 15, 2011 and will
continue until a suitable candidate has been found. To apply, send a
single PDF file including (1) a cover letter explaining your
qualifications and your motivation to join NeuroCure, (2) your CV
including list of publications and list of extramural funds, (3) a
statement of research interests, and (4) contact information for 3 academic referees to york.winter@charite.de and
marion.rivalan@charite.de . Informal inquiries to the same e-mail
address are welcome. For further information on NeuroCure, the city of
Berlin and the vibrant Berlin neuroscience community see:
www.neuroscience-berlin.de, www.neurocure.de,
www.neurocure.de/englisch/berlin.htm.
Contact: Prof. Dr. York Winter, NeuroCure - Cognitive Neurobiology,
Humboldt University, Dorotheenstrasse 94, 10117 Berlin, Germany, Tel.
+49-(0)30-450539738 Email york.winter@charite.de. www.winterlab.org

Doctoral Studies at Saarbruecken Graduate School for Computer Science (Saarland/Homburg),Germany

Would you like to join research-focused training in Germany?
Experience a stimulating and scientifically challenging atmosphere? Are you looking for close collaboration with dynamic faculty members in a unique international research environment on the German-French border in the middle of Europe?

Saarbrücken is your place to be. We offer a genuine doctoral program in English supported by the German Excellence Initiative. The Department of Computer Science at Saarland University runs the Graduate School in close cooperation with the internationally renowned research institutions:

- Max Planck Institute for Computer Science
- Max Planck Institute for Software Systems
- German Research Center for Artificial Intelligence (DFKI)

all located right next to each other on our Saarbrücken campus. This unique research environment gives our Ph.D. candidates the chance to collaborate with some 200 researchers at the postdoctoral or professorial level and over 250 doctoral students, covering virtually all areas of computer science.

Applicants should hold or be about to finish a Masters or an excellent Bachelor’s degree in computer science or in a related field. Doctoral candidates receive attractive scholarships and funding in all stages of the graduate program, which comfortably cover the moderate cost of living in Saarbrücken.

The upcoming application deadline for entering the Graduate School in April 2012 is: October 28, 2011.

Interested candidates are invited to apply online at www.sgscs.de.

Please don’t hesitate to contact us via cr@sgscs.de if you have any further questions.

3 PhD positions Biochemistry / Cell biology / Neurobiology

3 PhD positions Biochemistry / Cell biology / Neurobiology in an internationally well-known
research lab
(TV-L E13/2 - Projects funded by the Deutsche Forschungsgemeinschaft (DFG); 3 years - extension possible)

available

-       to study cytoskeletal and synaptic cytomatrix structures in neuronal development and synaptic function and plasticity.
-       to study protein interactions and functions of members of the syndapin family (F-BAR proteins)
-       to characterize novel cellular effector proteins involved in cytoskeletal and/or membrane (transport) processes
-       to study osmotic stress responses of the cortical actin cytoskeleton at both the cell biological and the molecular level

The Institute for Biochemistry I at the FSU Jena provides a stimulating research environment with excellent technical equipment in a recently completely reconstructed building right in the centre of Jena - one of the top-ranking and most lively biotech cities of Germany (ranked 2nd in the career atlas of all German cities – right behind Munich!).

The aim of our internationally well-known research team is to gain a molecular understanding of how the cortical actin cytoskeleton and specialized cytomatrix structures underlying the plasma membrane contributes to development, plasticity and function of cells and cellular networks, such as those formed by neurons in the brain.

We are currently studying several molecular players at the membrane/actin interface and are characterizing their role in both cytoskeletal and membrane dynamics (for work of our PhD students e.g. see Ahuja et al., 2007 Cell; Dharmalingam et al., 2009 J. Neurosci.; Schwintzer et al., 2011 EMBO J.).

We are seeking productive additions to our team
-       for generation and phenotypical analyses of KO-animals (several already available),
-       for studying membrane and actin dynamics in cell lines, in primary neuronal cultures, and in tissue sections and
-       for molecular/mechanistic studies e.g. using in vitro reconstitutions of actin dynamics and of membrane interactions and modulations, respectively.

Applicants should have a solid theoretical and practical knowledge of modern cell and/or neurobiology and experience in the generation and analyses of KO mice, in advanced methods of microscopy and/or in the biochemical and biophysical methods required for studying actin cytoskeletal dynamics and membrane interactions both in vitro and in vivo.

Candidates need to be distinguished by a high motivation to succeed in science and to work independently. However, it is also crucial to integrate into our team smoothly and to be a kind, efficient and reliable team-player.

Starting date is flexible. Due to the internationality of both our group and life in the young and vibrant university town Jena, knowledge of the german language is not required but fluent English is a prerequisite.

For further information please also see our webpage (http://www.biochemie.uniklinikum-jena.de/Biochemie+I/Stellenangebote.html).

Please send your complete application (incl. 2-3 ref. addresses) to

Prof. Dr. Britta Qualmann & Prov. Doz. Dr. Michael M. Kessels
britta.qualmann@mti.uni-jena.de

Methoden:
Applicants should have a solid theoretical and practical knowledge of modern cell and/or neurobiology and experience in the generation and analyses of KO mice, in advanced methods of microscopy and/or in the biochemical and biophysical methods required for studying actin cytoskeletal dynamics and membrane interactions both in vitro and in vivo.

Anfangsdatum: 1. Oktober 2011

geschätzte Dauer: 3-4 Jahre

Bezahlung: TV-L 1/2 E13

Veröffentlichungen:
for work of our PhD students e.g. see
Ahuja et al. 2007  Cell
Haeckel et al. 2008  J. Neurosci.
Dharmalingam et al. 2009  J. Neurosci.; Schwintzer et al. 2011  EMBO J.

Homepage: http://www.biochemie.uniklinikum-jena.de/Biochemie+I/Stellenangebote.html

Starting date is flexible

3 PhD positions Biochemistry / Cell biology / Neurobiology in an internationally well-known research lab (Jena),Germany

3 PhD positions Biochemistry / Cell biology / Neurobiology
in an internationally well-known research lab

(TV-L E13/2 - Projects funded by DFG)

available

- to study cytoskeletal and synaptic cytomatrix structures in neuronal development and synaptic function and plasticity.

- to study protein interactions and functions of members of the syndapin family

- to characterize novel cellular effector proteins involved in cytoskeletal and/or membrane (transport) processes

- to study osmotic stress responses of the cortical actin cytoskeleton at both the cell biological and the molecular level

The Institute provides a stimulating research environment with excellent technical equipment in a recently completely reconstructed building right in the centre of Jena - one of the top-ranking and most lively biotech cities of Germany (ranked 2nd in the career atlas of all German cities – right behind Munich!).

Our focus is on how the cortical actin cytoskeleton and specialized cytomatrix structures underlying the plasma membrane contributes to development, plasticity and function of cells and cellular networks, such as those formed by neurons in the brain. For work of our PhD students e.g. see Ahuja et al., 2007 Cell; Dharmalingam et al., 2009 J. Neurosci.; Schwintzer et al., 2011 EMBO J.).

Applicants should have a solid theoretical and practical knowledge and some experience in the generation and analyses of KO mice, in advanced methods of microscopy and/or in the biochemical and biophysical methods required for studying actin cytoskeletal dynamics and membrane interactions both in vitro and in vivo.

Candidates need to be distinguished by a high motivation to succeed in science, to work independently, to integrate into our team smoothly and to be kind, efficient and reliable team-players.

Starting date is flexible.

Fluent English is a prerequisite.

Further information: http://www.biochemie.uniklinikum-jena.de/Biochemie+I/Stellenangebote.html"