The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – in cooperation with the Friedrich Schiller University and the Max Planck Institute for Chemical Ecology are offering an international graduate training program.
The International Leibniz Research School (ILRS Jena) gives PhD students the possibility to prepare for their PhD exam in an ambitious program providing excellent research conditions. We invite applications for a PhD Student Position (Ref.No. 06/2011) Bioinformatic investigation and prediction of gene regulatory elements in pathogenic fungi Understanding and modeling of gene regulation in fungi requires knowledge about transcription factors (TFs) and transcription factor binding sites (TFBS). The increasing number of sequenced genomes and the huge amount of gene expression data together with the availability of computational methods allow to predict TFs and TFBS. In our research group, we surveyed the current knowledge about TFs in fungi and developed novel computational tools for TFBS prediction. Currently, we are establishing a database “FunTF” by using knowledge from literature about TFs and TFBS of pathogenic fungi. We reviewed methods of gene regulatory network reconstruction and developed novel bioinformatic tools for that task. Within this project, our novel methods for TFBS prediction will be applied and improved by integration of the experimental findings stored in our database FunTF. A novel tool that integrates the RNA-seq data with the FunTF knowledge should be created to allow reverse engineering of the regulatory networks. RNA-seq from the fungal data should be exploited to refine the understanding of the organization of regulatory elements. These elements will be studied and modeled in pathogenic fungi, in particular Aspergillus fumigatus and Candida albicans as well as the dermatophytes Arthroderma benhamiae und Trichophyton verrucosum. Special emphasis will be placed on the regulation of secondary metabolite gene clusters, which are in the research focus of the Hans Knöll Institute. We expect:
- a Master’s degree (or equivalent) in Natural or Life Sciences. Research at ILRS is centred around “Microbial and Biomolecular Interactions”. Candidates about to earn their degree are welcome to apply.
- high motivation and interest to join one of the research areas of ILRS
- an integrative and cooperative personality
- very good communication skills in English We offer:
- a top-level research environment
- efficient supervision by a team of supervisors
- a comprehensive mentoring program (cf. Program of Study)
- courses in state-of-the-art technologies and soft skills
- strong communication and interaction between the involved institutions
- Jena – City of Science: innovative business activities, successful scientific centres and a vibrant cultural scene around the famous Friedrich Schiller University Further information:
Dr. Reinhard Guthke, PI reinhard.guthke@hki-jena.de
Dr. Ekaterina Shelest, PI
ekaterina.shelest@hki-jena.de
Dr. Christine Vogler, ILRS Coordinator ilrs@hki-jena.de For the first step of the application procedure please acquaint yourself with the scientific projects offered on our website www.ilrs.hki-jena.de and thoroughly fill in the “Statement of Interest” form downloadable from this site. The application procedure is handled online exclusively via the ILRS website. Applications in English including the completed “Statement of Interest”, curriculum vitae, copies of relevant certificates (MSc, BSc, etc.), and references should be submitted to: ilrs@hki-jena.de Deadline for application: November 30, 2011.
The International Leibniz Research School (ILRS Jena) gives PhD students the possibility to prepare for their PhD exam in an ambitious program providing excellent research conditions. We invite applications for a PhD Student Position (Ref.No. 06/2011) Bioinformatic investigation and prediction of gene regulatory elements in pathogenic fungi Understanding and modeling of gene regulation in fungi requires knowledge about transcription factors (TFs) and transcription factor binding sites (TFBS). The increasing number of sequenced genomes and the huge amount of gene expression data together with the availability of computational methods allow to predict TFs and TFBS. In our research group, we surveyed the current knowledge about TFs in fungi and developed novel computational tools for TFBS prediction. Currently, we are establishing a database “FunTF” by using knowledge from literature about TFs and TFBS of pathogenic fungi. We reviewed methods of gene regulatory network reconstruction and developed novel bioinformatic tools for that task. Within this project, our novel methods for TFBS prediction will be applied and improved by integration of the experimental findings stored in our database FunTF. A novel tool that integrates the RNA-seq data with the FunTF knowledge should be created to allow reverse engineering of the regulatory networks. RNA-seq from the fungal data should be exploited to refine the understanding of the organization of regulatory elements. These elements will be studied and modeled in pathogenic fungi, in particular Aspergillus fumigatus and Candida albicans as well as the dermatophytes Arthroderma benhamiae und Trichophyton verrucosum. Special emphasis will be placed on the regulation of secondary metabolite gene clusters, which are in the research focus of the Hans Knöll Institute. We expect:
- a Master’s degree (or equivalent) in Natural or Life Sciences. Research at ILRS is centred around “Microbial and Biomolecular Interactions”. Candidates about to earn their degree are welcome to apply.
- high motivation and interest to join one of the research areas of ILRS
- an integrative and cooperative personality
- very good communication skills in English We offer:
- a top-level research environment
- efficient supervision by a team of supervisors
- a comprehensive mentoring program (cf. Program of Study)
- courses in state-of-the-art technologies and soft skills
- strong communication and interaction between the involved institutions
- Jena – City of Science: innovative business activities, successful scientific centres and a vibrant cultural scene around the famous Friedrich Schiller University Further information:
Dr. Reinhard Guthke, PI reinhard.guthke@hki-jena.de
Dr. Ekaterina Shelest, PI
ekaterina.shelest@hki-jena.de
Dr. Christine Vogler, ILRS Coordinator ilrs@hki-jena.de For the first step of the application procedure please acquaint yourself with the scientific projects offered on our website www.ilrs.hki-jena.de and thoroughly fill in the “Statement of Interest” form downloadable from this site. The application procedure is handled online exclusively via the ILRS website. Applications in English including the completed “Statement of Interest”, curriculum vitae, copies of relevant certificates (MSc, BSc, etc.), and references should be submitted to: ilrs@hki-jena.de Deadline for application: November 30, 2011.