We have 3 PhD and/or Postdoc positions available to study the role of the Hsp90 chaperone system in ER associated protein quality control. The projects are funded initially for three years with possible extension by grants from the German Research Association (DFG) and the Mukoviszidose e.V. Association. Work will focus on medically relevant client proteins of the Hsp90 chaperone system involved in Cystic Fibrosis (CF), Diabetes and liver disease and include translational approaches to develop “next generation” drugs for CF therapy.
References: Moffat et al. Biochemistry 47: 8203-8213 (2008); Lotz et al. J Cell Sci 121: 717-723 (2008); Hawle et al. Mol Cell Biol 26: 8385-8395 (2006); Brychzy et al. EMBO J 22: 3613-3623 (2003); Lotz et al. J Biol Chem 278: 17228-17235 (2003).
Your profile: Master degree or Diploma in Biochemistry, Cell Biology, Molecular Biology or Physiology with expertise in breeding and genotyping of mouse models.
To apply, candidates should provide a letter of motivation and statement of research interests, their CV, 2 letters of recommendation and a copy of their degree to:
PD Dr. Wolfgang M. J. Obermann, Institute for Physiology, Building MA 3/157
Ruhr-University Bochum, Universitätsstr. 150, 44801 Bochum, Germany
Wolfgang.Obermann@rub.de
References: Moffat et al. Biochemistry 47: 8203-8213 (2008); Lotz et al. J Cell Sci 121: 717-723 (2008); Hawle et al. Mol Cell Biol 26: 8385-8395 (2006); Brychzy et al. EMBO J 22: 3613-3623 (2003); Lotz et al. J Biol Chem 278: 17228-17235 (2003).
Your profile: Master degree or Diploma in Biochemistry, Cell Biology, Molecular Biology or Physiology with expertise in breeding and genotyping of mouse models.
To apply, candidates should provide a letter of motivation and statement of research interests, their CV, 2 letters of recommendation and a copy of their degree to:
PD Dr. Wolfgang M. J. Obermann, Institute for Physiology, Building MA 3/157
Ruhr-University Bochum, Universitätsstr. 150, 44801 Bochum, Germany
Wolfgang.Obermann@rub.de