Neuro-immune interaction in the gut:
Approximately 10 % of patients who suffered from a bacterial gastroenteritis develop persistent mucosal microscopic inflammation associated with prolonged symptoms of abdominal pain and altered defecation. Accumulating evidence shows that low grade inflammation has a major effect on the phenotype and function of afferent nerve fibers, especially nociceptive nerve fibers, leading to abnormal pain perception. In parallel with clinical studies, we have developed animal models of abnormal visceral pain perception (visceral hypersensitivity) to study the interaction between nerves and the immune system, including a mouse model of post-infectious inflammation. The present project focuses on the immune cells involved and on the potential contribution of commensal bacteria as trigger to maintain the state of immune activation.
Techniques:
In vivo studies: mouse handling and manipulation, adoptive transfer
In vitro studies: FACS analysis, (micro-)RNA extraction, real-time PCR, cell cultures and co-cultures and immunohistochemistry
Requirements:
We seek motivated graduates (Biology/ Biomedical Sciences/ Medicine) with an interest in neuro-immunology.
Employment basis: temporary for specified period
Duration of the project: 4 year contract
Maximum hours per week: 36
Salary: Phd students start with a salary of €1700 (nett) with a yearly growth of €2300 gross per month
Please contact Dr. Mira Wouters (+32(0)16 33 02 38, mira.wouters@med.kuleuven.be) for more details