1 PhD student position
in structure-function studies of small GTPases in cancer
in the Mechanism and Biosensors of small GTPases Group of Daniel Abankwa at the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku Finland (www.btk.fi). Turku is a beautiful old city located in south-western corner of Finland surrounded by a magnificent archipelago with thousands of small islands (http://www.saaristo.org/eng/).
Our research focuses on the membrane organization and signaling activity of small GTPases of the Ras-, Rho- and Rab-family. We have recently described a novel switch III region for Ras proteins, which is associated with formerly unappreciated conformers of membrane bound Ras. This mechanism profoundly influences Ras biology (Abankwa D et al. (2008) Embo J 27(5): 727-735; Abankwa D et al. (2010) PNAS 107(3): 1130-1135). We will be using cutting-edge cellular imaging (Fluorescence Lifetime Imaging Microscopy, FLIM, and STED-nanoscopy), high-throughput approaches (high-content and cytometer chemical- and RNAi-screening) and animal models to answer exciting questions around this newly discovered mechanism.
The Centre for Biotechnology offers state-of-the-art research facilities for bioimaging, proteomics, genomics, crystallography, which support excellence in research in the greater Turku area. The Cell Imaging Core features very good equipment for life-cell imaging, high-content and confocal microscopy, as well as state of the art FACS service and high-throughput flow cytometry. In particular, it serves as the Nordic reference site for the Leica STimulated Emission Depletion (STED)-superresolution microscope.
We are looking for candidates with top academic qualifications and high self-motivation, who recently earned their masters degree in a discipline related to biophysics. Practical experience with two of the following skills is a requirement: protein purification, quantitative fluorescence imaging, cellular transformation assays, FRET/FLIM, FCS or related spectroscopic methods. Practical experience with molecular biology techniques (cloning, PCR etc.) is desirable.
The stipend 1400 €/month net (not taxable) is commensurate with typical university salary scales for graduate students.
Please send preferably as one merged pdf: a short CV that highlights your most outstanding achievements, as well as the email contacts of 2-3 referees (these may also be course advisors) and a brief description of your specific motivation to join the group (approx. 1/2 A4 page) to daniel.abankwaATbtk.fi with the subject line ‘research candidate’. The positions should commence early 2011. Applications are open from January 2011 until the positions are filled.
in structure-function studies of small GTPases in cancer
in the Mechanism and Biosensors of small GTPases Group of Daniel Abankwa at the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku Finland (www.btk.fi). Turku is a beautiful old city located in south-western corner of Finland surrounded by a magnificent archipelago with thousands of small islands (http://www.saaristo.org/eng/).
Our research focuses on the membrane organization and signaling activity of small GTPases of the Ras-, Rho- and Rab-family. We have recently described a novel switch III region for Ras proteins, which is associated with formerly unappreciated conformers of membrane bound Ras. This mechanism profoundly influences Ras biology (Abankwa D et al. (2008) Embo J 27(5): 727-735; Abankwa D et al. (2010) PNAS 107(3): 1130-1135). We will be using cutting-edge cellular imaging (Fluorescence Lifetime Imaging Microscopy, FLIM, and STED-nanoscopy), high-throughput approaches (high-content and cytometer chemical- and RNAi-screening) and animal models to answer exciting questions around this newly discovered mechanism.
The Centre for Biotechnology offers state-of-the-art research facilities for bioimaging, proteomics, genomics, crystallography, which support excellence in research in the greater Turku area. The Cell Imaging Core features very good equipment for life-cell imaging, high-content and confocal microscopy, as well as state of the art FACS service and high-throughput flow cytometry. In particular, it serves as the Nordic reference site for the Leica STimulated Emission Depletion (STED)-superresolution microscope.
We are looking for candidates with top academic qualifications and high self-motivation, who recently earned their masters degree in a discipline related to biophysics. Practical experience with two of the following skills is a requirement: protein purification, quantitative fluorescence imaging, cellular transformation assays, FRET/FLIM, FCS or related spectroscopic methods. Practical experience with molecular biology techniques (cloning, PCR etc.) is desirable.
The stipend 1400 €/month net (not taxable) is commensurate with typical university salary scales for graduate students.
Please send preferably as one merged pdf: a short CV that highlights your most outstanding achievements, as well as the email contacts of 2-3 referees (these may also be course advisors) and a brief description of your specific motivation to join the group (approx. 1/2 A4 page) to daniel.abankwaATbtk.fi with the subject line ‘research candidate’. The positions should commence early 2011. Applications are open from January 2011 until the positions are filled.