3 Postdoctoral Researchers and 2 Doctoral Student positions, University of Helsinki, Finland

3 POSTDOCTORAL RESEARCHERS AND
2 DOCTORAL STUDENT POSITIONS

in fungal pathobiology. Two years for postdoctoral researchers and four years for doctoral students. Start date: Immediately.

We are looking to recruit highly motivated postdocs and doctoral students to work in Applied bioinformatics, Functional genomics, Evolutionary fungal biology, or Fungal molecular biology with primary focus on developing a comparative genomics platform on Fungal Pathobiology.

Fungi (saprotrophs, pathogens, mutualists) associated with cultivated plants and forest trees are known to play fundamental roles in the health of cultivated crops and boreal forests, influencing their vitality and productivity. Comparisons at genomic and gene expression levels between the contrasting plant-fungus situations will help to forward our understanding of key elements in the interactions and the evolution of the various forms. Increasing wealth of fungal genomes sequences is becoming available. The key for maximal usage of data is in advanced methods of bioinformatics. Our aim is to develop a strong platform of theoretical expertise in fungal pathogenomics which will facilitate research and educational goals. This effort is supported by the Finland Distinguished Professor (FiDiPro) programme (http://www.fidipro.fi/pages/home.php).
Location: Departments of Forest sciences and Agricultural Sciences. Our laboratory is situated within the Viikki campus of the University of Helsinki. The research group is part of the larger Viikki Biocenter Research Organization with access to state of the art experimental and bioinformatics facilities (http://www.biocenter.helsinki.fi/).

According to University of Helsinki Statutes a person selected for the post of postdoctoral researcher is required to have a doctoral degree and the ability to do independent scientific work as well as having the necessary teaching skills.

A person selected for the post of doctoral student is required to have a Master’s degree and an accepted research plan. In addition, he/she is required to have shown, when acquiring his/her degree and otherwise, the ability and motivation for postgraduate studies and completion of a doctoral degree in accordance with a study and research plan.

Applicants: Students and postdocs with good academic records and strong skills in Applied bioinformatics, functional genomics, evolutionary biology and molecular biology are welcome to apply to any of the positions. Knowledge in plant or forest pathology and mycology are considered as additional merits. A good knowledge of English is required.

The salary for postdoctoral researchers will be, depending on the appointee’s performance and experience approximately between 34 000 and 49 000 (postdocs), and between 23 600 and 42 000 (doctoral students) euros per annum.

Written applications should be sent to Prof. Fred O. Asiegbu, Department of Forest Sciences, P.O. BOX 27 (Latokartanonkaari 7), FI-00014, University of Helsinki, Finland to arrive no later than December 22nd, 2010 by 15.45 (local Helsinki time).

The applications should contain CV, list of publications, and three referees’ reports. In addition, those applying for the doctoral student positions should also submit a research and study plan.
For further information on academic portfolio and on the assessment of teaching skills see www.helsinki.fi/yliopistoportfolio.

For further information about these positions, please contact:
1. Professor Fred O. Asiegbu, Department of Forest Sciences, University of Helsinki,
Tel: +358-9-19158109, e-mail: fred.asiegbu@helsinki.fi; http://blogs.helsinki.fi/forestpathology/

2. Academy professor Jari P.T. Valkonen, Department of Agricultural Sciences, University of Helsinki, Tel. +358-9-19158387, e-mail: jari.valkonen@helsinki.fi; http://www.helsinki.fi/ppvir/research/index.html

3. Professor Yong-Hwan Lee, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea Tel: +82-2-8804674, e-mail: yonglee@snu.ac.kr; http://cfgp.snu.ac.kr
Helsinki, 13 joulukuu 2010

Central Administration
www.helsinki.fi/university

PhD Studentships in Plant Science : Sheffield United Kingdom

Sainsbury PhD Studentships in Plant Science

Enhanced postgraduate studentships, each for four years, starting in October 2011, will once again be awarded by the Gatsby Charitable Foundation, one of the Sainsbury Family Charitable Trusts. Each of the supervisors below will select a candidate who will then compete at interview, with Sainsbury Undergraduate students, for one of up to three Sainsbury PhD Studentships. Interviews will be held in London on Friday, 4 March 2011. It would be expected that the studentship holder spend six months during their 3rd or 4th year at another university/institute to gain additional experience.

Interested applicants should write, attaching a CV, before 27 January 2011, to one or more of the following:

‘Investigating whether stomatal development can be optimised for current and future CO2 environments’

Professor Julie Gray, Molecular Biology & Biotechnology, Univ of Sheffield, Western Bank, Sheffield S10 2TN Email: j.e.gray@sheffield.ac.uk Tel: +44 (0) 114 222 4407

Functional Genomics and Cell Signaling: Group Leader position with start-up package at the Biotechnology Centre of Oslo,Norway

Functional Genomics and Cell Signaling: Group Leader position with start-up package at the Biotechnology Centre of Oslo
Applications are invited for a group leader position at the Biotechnology Centre of Oslo (BiO, www.biotek.uio.no). BiO is a centre for

molecular biology, biotechnology and bioinformatics within the University of Oslo. A call is now open for a new group leader to start at BiO in 2011. The successful candidate for the position will be offered a fi xed-term, 5-year contract, which is renewable for up to 5 additional years subject to evaluation.
The successful applicant for the position will be responsible for building up a strong research group and initiate a new independent research program in functional genomics with focus on genetic analysis of signaling pathways, imaging of signaling, or chemical biology and high throughput cell biology. Relevant research areas also include other aspects of functional genomics

and biotechnology. Qualification requirements include a PhD or equivalent degree, appropriate postdoctoral training, experience with supervision and a track-record of high-impact publications in top journals of biology or medicine.

In addition, considerable weight will be put on the research plan proposed by the candidate and on how this will integrate and synergize with the activity in the region.
For further information and a more comprehensive job description visit our website www.biotek.uio.no. Please contact Centre Director, Professor Kjetil Taskén (kjetil.tasken@biotek.uio.no) with inquiries. Applications should be addressed to the Director

and sent electronically as a single pdf-fi le to the Biotechnology Centre of Oslo at recruitment@biotek.uio.no to arrive no later than

15th of February, 2011 marked REF. NO.: 2010/13469.

he DFG Research Training Group 1727 (GRK 1727) “Modulation of Autoimmunity” seeks to recruit 13 graduate students (biology, biochemistry, chemistry, and medicine)

The DFG Research Training Group 1727 (GRK 1727) “Modulation of Autoimmunity” seeks to recruit 13 graduate students (biology, biochemistry, chemistry, and medicine)
The newly established DFG Research Training Group “Modulation of Autoimmunity” (GRK1727, Spokesperson: Prof. Detlef Zillikens) seeks to employ 13 graduate students from the areas of biology, biochemistry, chemistry and medicine.

While the incidence of autoimmune diseases is increasing, general immunosuppression is still the mainstay of therapy. This is associated with a significant morbidity and mortality. Therefore, the major goal of GRK1727 is the identification and evaluation of novel therapeutic targets and strategies for autoimmune diseases. The principle investigators involved are from the Institutes of Immunology, Chemistry, Anatomy, Systemic Inflammation Research and Medical Microbiology as well as from the Clinical Departments of Rheumatology and Dermatology at the University of Lübeck and the Research Center Borstel.
We are seeking to recruit candidates with a strong interest in translational immunological research. Preference will be given to candidates experienced in experimental disease models. The University of Lübeck is an equal opportunities employer. Applications from female candidates are strongly encouraged. In case of compatible qualifications, preference will be given to people with disabilities.

Detailed information on individual projects and participating principal investigators will be available from Prof. Ralf Ludwig (ralf.ludwig@uk-sh.de). In addition to their project-related work, students of the GRK1727 will benefit from a structured qualification and mentoring program. Salaries are according to E13 1/2 positions (TV-L) for a maximum of 3 years. After successful completion of the program and depending on the initial degree of the student, the following degrees can be awarded by the University of Lübeck: Dr. rer. nat., Dr. hum. biol., and Dr. med.. The prerequisite for entering the program is either a master or diploma degree.

Applications including CV, certificates, and letters of recommendation from 2 previous mentors should be sent in PDF format to Prof. Ralf Ludwig (ralf.ludwig@uk-sh.de). The deadline to submit your application is January 20, 2011. Applications failing these requirements will not be considered. Selected applicants will be invited to participate in a 2- day interview in Lübeck (3.-4.02.2011); partial reimbursement for travel expenses will be provided. Successful candidates will begin to work in Lübeck on April 1, 2011.

PhD scholarship in Rational Evolution of Enzymes , Technical University of Denmark, DTU Chemistry

We are looking for talented candidates for an international-level PhD degree in Rational Evolution of Enzymes at The Technical University of Denmark (DTU), DTU Chemistry, funded by the Danish National Research Council for Technology and Production. Approximate starting date April 1 2011.
This new, international research project involves the study of the copper-containing enzymes known as laccases: Why did they evolve to their particular current structures, and how are these structures evolutionary optimized for stability and function under extreme environmental conditions, in particular high temperature?
The theoretical knowledge gained in the early part of the project will be used to rationally guide the evolution of new breeds of superstable laccases in the lab. The research area of computational protein evolution is of growing importance, because of the need to process increasingly complex information in the search for new industrial enzymes, both within academic research and within the private sector.

Qualifications

Candidates should have a master’s degree in engineering or science or a similar degree with an academic level equivalent to the master’s degree. Both theoretical and experimental skills need to be proven. Relevant theoretical skills: Computational biology/chemistry, mathematical modeling, biophysics, quantum chemistry, computers/programming. Relevant experimental skills: General Lab experience, protein chemistry, protein expression, mutagenesis, and/or screening.

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.

Further information
Further information may be obtained from Dr. Kasper P. Kepp, e-mail: kpj@kemi.dtu.dk.
You can read more about our research on www.kpje.com.
Do NOT send applications to this e-mail address, but use the electronic submission system – see below!

Application
We must have your online application by 15 February 2011. Please apply for the position at www.dtu.dk/Vacancy. Please open the link “apply for this job online”, fill in the application form and attach the following documents;

• A letter motivating the application (cover letter)
• Curriculum vitae
• Grade transcripts and BSc/MSc diploma
• Conversion of grade averages to Danish grades (see guidelines and excel spreadsheet for the conversion here).

Candidates may apply prior to obtaining their master’s degree, but cannot begin before having received it.
All interested candidates irrespective of age, gender, race, handicap, religion or ethnic background are encouraged to apply.

PhD Studentship Bacterial Pathogenesis : Ashworth Laboratories, Kings Buildings, University of Edinburgh

The post
A BBSRC/CASE PhD studentship is available for 3 years in the School of Biomedical Sciences. The post is based at the Centre for Immunity, Infection and Evolution, Ashworth Laboratories, King’s Buildings campus close to the city centre. Excellent scientific environment and research facilities. This is a unique training opportunity in molecular microbiology, bacterial pathogenesis and drug discovery.

The project
The multihost pathogenic actinomycete Rhodococcus equi, a facultative intracellular parasite of macrophages, is the causative agent of a severe respiratory disease of horses. R. equi is also an emerging human opportunistic pathogen associated with severe, tuberculosis-like infections in HIV-infected patients and immunosuppressed individuals. We recently sequenced and analysed the genome of R. equi (Letek et al. 2010, PLoS Genet. 6(9): e1001145). In this project we will use genome-wide expression profiling and mutant analysis to identify and characterize the mechanisms used by R. equi to cause infection and persist in the environment. The insight into R. equi infection biology derived from these studies will provide a rational framework for translational research in R. equi vaccine development. It will also enhance our knowledge of intracellular parasitism and, by comparison, the infection mechanisms of related pathogens, particularly Mycobacterium tuberculosis.

The candidate
Biomedical or biological sciences graduate. Applicants should have (or expect to obtain) a first or upper second-class degree. A Masters degree or equivalent laboratory experience in the field would be an advantage. You should be a hard-working, strongly motivated, intellectually capable individual willing to undertake a research career and to carry out a demanding project through to completion. You must have enthusiasm, initiative, good interpersonal skills and capacity to work independently and as part of a team.

Funding note
Candidates must be eligible by residence for a UK BBSRC studentship (Candidates from EU countries out with the UK are eligible for a full award if they have completed three years’ full time education, or employment, in the UK, immediately prior to the studentship).
Applications with CV, cover letter and contact details of two academic referees to Prof. Jose Vazquez-Boland (jvbgroup@ed.ac.uk)

Closing Date for Applications: 5th January 2011
Start date: September / October 2011

Post-doctoral position,Institute of Molecular and Clinical Immunology,University of Magdeburg

Post-doctoral position available


A post-doctoral position is currently available within the Systems Biology group of the Institute of Molecular and Clinical Immunology at the Otto-von-Guericke University in Magdeburg. The Institute is composed of 10 Research Groups focused on characterizing the role of adaptor proteins in T-cell signaling. Further information on the Institute is available via our web site http://www.med.uni-magdeburg.de/imki.html


The Institute is also an active participant in the BMBF funded FORSYS program. The candidates will support current efforts to establish a qualitative model of T-cell signaling and are expected to contribute to the development of a quantitative model of T-cell activation.

Salary for these positions is based on the TV-L scheme.

Candidates should possess a Ph.D. and ideally have experience in T-cell biology and/or signal trans-duction, with a solid background in protein biochemistry. An interest in theoretical immunology, mathematics, molecular biology, and/or microscopy is also desirable. Fluency in the English language is required.
The Otto-von-Guericke University is an equal opportunity employer and women are encouraged to apply. Candidates should submit a CV, list of publications, and the names and contact details of 2 referees to:

Jonathan A. Lindquist, Ph.D.
Head of Systems Biology
Institute of Molecular and Clinical Immunology
Otto-von-Guericke University
Leipziger Str. 44
D-39120 Magdeburg
Germany
Tel. +49 391 67 13660
Fax +49 391 67 15852
Email: Jon.Lindquist@med.ovgu.de

Application Deadline: December 20, 2010

PhD Studentship Neuroscience

Department of Pharmacology

School of Pharmacy / MRC PhD Studentship
Applications are invited for a 42 month PhD studentship funded by the Medical Research Council and the School of Pharmacy commencing early 2011.

Mechanisms underlying synapse-specific clustering of GABAA receptors
In this project we aim to determine how GABAA receptor subtypes become selectively clustered at specific classes of inhibitory synapse. The fundamental principle arising from previous work is that each presynaptic terminal recognises its postsynaptic partner, while each postsynaptic site recognises the synaptic bouton that innervates it. In response to this recognition, the postsynaptic site sequesters, inserts or captures receptors appropriate for the function of that type of synapse. The question is, how do the pre- and post-synaptic elements recognise each other. Two approaches to this question are being employed (outlined below).

Main Methods and Techniques to be Employed
The ability of GABAergic neurones to form functional synapses when co-cultured with the HEK 293 cells expressing defined subtypes of GABAA receptors is assessed using immunofluorescence, live cell imaging, FM dye- or synaptotagmin- antibody-uptake, electron microscopy and dual whole cell recordings.
In parallel, methods are being developed to generate pure extracellular domains of pentameric GABAA receptors and single subunits using mutagenesis, heterologous expression in mammalian cells lines and insect cells. These will be used to affinity-purify proteins that interact with the extracellular domains of GABAA receptors.

The project is in progress in well equipped, recently refurbished laboratories. Neuroscience at the School of Pharmacy is strong and growing, with 13 research groups in a supportive, friendly environment in the heart of central London’s Bloomsbury. We employ a wide range of techniques and expertise and have a strong interest in inhibitory transmission, receptors and circuitry.

Entry Requirements
Candidates must have, or expect to obtain, a first or upper second class BSc in Biochemistry, Molecular Biology, Neuroscience, Pharmacology or a cognate discipline.
Due to funding restrictions, only HOME students are eligible for the full award. EU students are eligible for a tuition fees award only. Overseas candidates are not eligible and regretfully enquiries and applications from ineligible candidates will not be acknowledged.

Stipend
The studentship covers tuition fees and a maintenance stipend for 42 months pegged to the MRC in London rate (approx £15,740).

Informal enquiries may be addressed to the supervisor:
Name: Dr Jasmina Jovanovic
Department: Pharmacology
Telephone: 0207 753 5887
Fax: 0207 753 5902
E-mail: jasmina.jovanovic@pharmacy.ac.uk
Web profile: http://www.pharmacy.ac.uk/jasmina_jovanovic.html

Applications
The application form is available online at:
http://www.pharmacy.ac.uk/fileadmin/documents/msc/postgrad-appform-new.pdf
Candidates should send the completed application form, CV, personal statement explaining their interest in the project and the names and contact details (including email) of two academic referees to :
Lauren O’Brien, Registry Officer, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, tel: 020 7753 5958, fax: 020 7753 5829.
Queries about application may be addressed to phd@pharmacy.ac.uk
The studentship will be held open until a suitable candidate is appointed.
Informal enquiries to Dr Jovanovic or Prof Thomson.

http://www.pharmacy.ac.uk/neuro.html

PhD student in cancer research, Karolinska Institute, Sweden

Department of Oncology-Pathology
Research Group Leonard Girnita
Last date for applications: December 27 2010

The successful candidate will work within an international and multidisciplinary research environment. All research is performed as part of a team and results discussed in regular group meetings. The research group focuses on signaling pathways dysregulated in cancer, in particular in clarifying the role of the coross-talk between G-protein coupled receptors (GPCR) and tyrosine kinase receptors (RTK). Techniques to be used include cell culture, western transfer analysis, confocal microscopy and BRET/FRET analysis to identify protein interactions. For more information:

http://ki.se/ki/jsp/polopoly.jsp?d=24301&a=67014&l=en

The PhD student will study signaling pathways and their implication in the understanding, diagnosis and treatment of human cancers. They will be expected to learn and apply various laboratory techniques and evaluate these results based on a good working knowledge of current literature. Full support will be given in technique training although high levels of self motivation and enthusiasm to learn will be expected.
The successful applicant will enter a 3-6 month research preparatory course with the possibility to apply for admission to the 4 year PhD program. The lab is situated within the Cancer Centrum Karolinska at the Department of Oncology-Pathology (www.ki.se/). For employment as a PhD student it is required that the application for admission be accepted. Information about the PhD studies, admission requirements and admission rules can be found at http://ki.se/ki/jsp/polopoly.jsp?l=en&d=270

For the first two years the student is awarded a doctoral student allowance (not employment) that after the half-time control will be transformed into a paid position as a PhD student (employment). The PhD program is full time for 4 years and consists of full time project work with taught courses alongside.

Applications are welcomed from talented students with a good degree in a medical, biomedical or related subject. Earlier experience with techniques in cell culture, western transfer analysis or good working knowledge in other common laboratory Applications are welcomed from talented students with a good degree in a medical, biomedical or related subject. Earlier experience with techniques in cell culture, western transfer analysis or good working knowledge in other common laboratory techniques will be considered an advantage. Good spoken and written English is essential and is a requirement for admittance to the PhD program. The demonstrated ability to work as part of a team and a high standard of spoken and written communication should be identifiable from information given in the CV.

PhD positions in Population Genetics, Vienna Graduate School of Population Genetics, Austria

Over the past years, Vienna has developed into one of the leading centers of population genetics. The Vienna Graduate School of Population Genetics has been founded to provide a training opportunity for PhD students that builds on this outstanding on site expertise.

We invite applications from highly motivated and outstanding students with a background in one of the following disciplines: bioinformatics, statistics, evolutionary genetics, functional genetics, theoretical and experimental population genetics. Students from related disciplines, such as physics or mathematics are also welcome to apply.

Available topics include:
- New algorithm and models to analyze population genetic massive parallel sequence data
- The footprint of adaptive gene introgression after secondary contact
- Probabilistic models for the population genetics of molecular evolution
- The genetics of two closely related species of Aquilegia
- Evolution of gene expression in Drosophila
- Association mapping in outbred Drosophila populations
- Measuring interspecific gene flow by massively parallel sequencing
- Genetic basis of local adaptation
- Admixture mapping with Bayesian probabilistic models for genome wide population genetic data
- Mathematical models of spatially varying selection in subdivided populations
- Functionally significant genetic variation in lifespan in natural populations
- Statistical methods for detecting selective sweeps using genome-wide data
- Population genetic estimators from NGS data

Applications need to be received by 13.02.2011 and include CV, motivation letter, university certificates and an indication of the two preferred topics in a single pdf. Two letters of recommendation need to be sent directly by the referees.

All information about the about the Vienna Graduate School of Population Genetics, the training program and the application procedure can be found at www.popgen-vienna.at

PhD scholarship on symbiotic growth depressions in bioenergy and forage crops in Denmark

The Biosystems Division at Risø DTU has an open PhD position within a project to study mechanisms behind mycorrhiza-induced growth depression in grasses and methods to mitigate such depressions. The project is embedded in the Ecosystems Programme (ECO) focusing on interactions between ecosystems, energy production and climate change.

Project description
Growth depressions caused by arbuscular mycorrhizal fungi (AMF) are frequently observed in cereals and other grasses in mesocosms and may result in ‘hidden’ yield losses in the field. Such growth depressions are usually assigned to carbon drain by the fungi but this is poorly supported by experimental evidence. This project shall test the new hypothesis that AMF-colonised plants become P limited due to impaired function of direct P uptake at the root surface. The project shall also investigate methods to mitigate this assumed loss-of-efficiency in P uptake. Two crop plants with contrasting patterns of mycorrhizal growth response, ryegrass and lucerne, will be studied in parallel with the sequenced model plants, Brachypodium distachyon and Medicago truncatula.

• Your PhD project will focus on Brachypodium-related parts of the project:*

• Physiological characterisation of P uptake via two pathways (direct and AMF-mediated) in Brachypodium distachyon grown at ambient and elevated CO2
• Isolation and expression analysis of Pi transporter genes and miRNAs in AMF-colonised plants and their relationship to plant P uptake in Brachypodium model and Lolium perenne crop plants
• Transformation of B. distachyon with a subset of selected candidate genes using Agrobacterium tumefaciens
• Characterization of P uptake by transgenic plants and contribution to the development of model for regulatory mechanisms underlying mycorrhizal growth responses in crops

The project is funded by The Danish Council for Independent Research | Technology and Production Sciences and involves collaborators in Denmark, Australia and USA. You will join the mycorrhiza project group and part of your work will be carried out at the breeding company DLF Trifolium under supervision by researchers with core expertise on transformation of grasses. The project will be embedded in a dynamic and productive research environment including other PhD students, Researchers and Technicians.

Qualifications
We seek an energetic and skilled candidate with a Master’s degree in plant biology or a similar degree with an academic level equivalent to the Master’s degree in plant biology. The successful applicant will be highly motivated, will have demonstrated ability to work independently, and will have experience in the use of molecular-physiological methods. Experimental experience with plant-microbe interactions is an advantage but not a requirement. Ability for easy going communication (English) and mutual commitment to effective team work are highly desired. The work requires a driving licence.

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

Salary and appointment terms

Salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years with start on 1 April 2011. The places of work are Risø DTU and DLF Trifolium.
Further information
Further information about the project may be obtained from Iver Jakobsen, ivja@risoe.dtu.dk, tel. +45/46774154. You can also read more about the Biosystems Division and Risø DTU at risoe.dtu.dk.

Application

We must have your online application by 20 December 2010. Please apply online on www.dtu.dk/vacancy and open the link "apply for this job online, fill in the application form and attach the following documents:
a) A letter motivating the application (cover letter)
b) Curriculum vitae
c) Grade transcripts and BSc/MSc diploma
d) Conversion of grade averages to Danish grades (see guidelines and excel spreadsheet for the conversion here).
Candidates may apply prior to obtaining their master’s degree, but cannot begin before having received it.
All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

PhD Studentships Medical and Human Sciences , University of Manchester,UK

Faculty of Medical and Human Sciences PhD Studentships 2011

The Faculty of Medical and Human Sciences is an internationally renowned centre for research and teaching within the applied health sciences. This reputation was further enhanced during 2009 with the launch of the Manchester Academic Health Science Centre (MAHSC), a partnership between the University of Manchester and six NHS Trusts aiming to advance scientific discovery and its translation into patient benefit.

Research opportunities span both the biomedical (genetics, tissue engineering, pharmaceutics) and health (psychology, epidemiology, primary care) sciences with extensive training in multidisciplinary areas. Our PhD training also incorporates transferable skills in aspects such as public engagement, scientific writing and career management to provide an unrivalled depth of support.

The Faculty is currently offering a number of 4-year PhD studentships to UK/EU nationals seeking PhD places commencing October 2011. Funding will provide full support for tuition fees, all associated project costs and an annual tax-free stipend at Research Council rates (2010 rate was £13, 590). A generous allowance towards the costs of attending external seminars and conferences will also be provided. Some of our projects provide opportunities for external training placements within industry or partnering institutes.

Projects are available within six priority themes:

Basic bioscience underpinning health
Biotechnology and biopharmaceutical development
Environmental and social influences affecting health
Mental health and wellbeing
Populations and public health
Regenerative medicine – application and advancement

A list of available projects can be found from the link below with applications for the majority of studentships open until Monday 10 January 2011.

http://www.mhs.manchester.ac.uk/postgraduate/studentships/

PhD in Bio-Chemistry, University of Oxford,UK

PhD Studentships

Deadline for applications: 7 January 2011

The Department of Biochemistry in collaboration with departments in the Medical Sciences and Mathematical, Life and Physical Sciences offer PhD studentships for research in wide ranging areas of biochemistry, molecular biology, biomedicine, biophysics and computational biochemistry. In your application for admission to a programme of study, you must indicate which studentship(s) you wish to be considered for. Alternatively, candidates may bring their own scholarships or sponsorships to support their studies, and will need to provide relevant information on their aplication for admission.

Applications for admission received by the closing date of a scholarship will be considered if the candidate meets the scholarship academic, nationality and residence eligibility criteria.

A list of Studentships and the Programmes of Study they support can be found at: http://www.bioch.ox.ac.uk/aspsite/index.asp?sectionid=phdstudentships
http://www.bioch.ox.ac.uk/aspsite/index.asp?sectionid=gradprogramme
http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=350

BBSRC Doctoral Training Grant Studentships (Fees and Living Allowance) for research under the remit of the BBSRC ‘Molecular Biochemistry and Chemical Biology’. UK and other EU nationals who have resided in the UK for at least 3 years by the 1st of September if starting their PhD on 1.10.2011 are eligible to apply for full funding. Other EU candidates are eligible for fees-only studentships, and are invited to also apply for the Scatcherd Scholarship and University College War Memorial scholarships and any other scholarships of the Univeristy or Colleges that might complement a fees-only studentship.

Clarendon Fund Scholarships. We strongly encourage non-EU candidates to indicate an interest in these and any other scholarships of the Univeristy or Colleges for which they are eligible.

Studentships awarded by the Cancer Research Centre via the Gray Institute to support doctoral studies in several departments, including Biochemistry.

Studentships awarded by Doctoral Training Centres (DTC). Applications for studentships and admission must be made directly to the respective doctoral training centre. Successful candidates will follow a specialized training programme and have opportunites to choose areas of research in Biochemistry and other departments.

Medical Sciences Division Doctoral Training Centre Wellcome Trust Studentships for:
DPhil in Chromosome and Developmental Biology
DPhil in Structural Biology
DPhil in Neuroscience
DPhil in Infection, Immunity and Translational Medicine

Mathematical, Physical and Life Sciences Doctoral Training Centre UK Research Council and Industry Studentships for:
Integrative Systems Biology
Life Sciences Interface
Systems Approaches to Biomedical Science (Collaborative with Industry)

How to apply
Please ensure that your application is made online and is complete by the deadline and preferably earlier. Please apply according to the guidance provided at:

http://www.bioch.ox.ac.uk/aspsite/index.asp?sectionid=howtoapply and
http://www.ox.ac.uk/admissions/postgraduate_courses/apply/application_guide.html

For any enquiries please Email dgs@bioch.ox.ac.uk.

PhD Opportunities in a First Class Research Environment

Hannover Biomedical Research School, as part of Hannover Medical School (MHH), invites applications for its three PhD programs to commence in October 2011.

Our offer
HBRS is one of Germany’s leading graduate schools, funded by the Excellence Initiative and offering top-level research, education and training possibilities. Under this umbrella our three international PhD programs Infection Biology, Molecular Medicine and Regenerative Sciences provide fully-funded studentships for a three-year course. In all three programs the focus is placed on individual research projects, complemented by program specific seminars as well as an individualized curriculum comprising lab and soft-skill courses, congresses, symposia and summer schools. Communication and teaching language throughout HBRS is English. Upon graduation students are awarded a PhD – life scientists may alternatively choose a Dr. rer. nat.

Our expectations

All three PhD programs are aimed at highly motivated postgraduates with a background in Medicine, Veterinary Medicine or the Life Sciences. The PhD program Regenerative Sciences is also open to students from a Materials Science discipline. We are looking for enthusiastic candidates of all nationalities who have a keen interest in one of the research foci offered by our programs. Excellent written and spoken English skills are required.

Our programs

PhD Infection Biology: The program’s objective is to investigate the complex interactions between host and pathogen as well as basic research with the combined tools of immunology, microbiology, virology, cell biology and molecular biology. For more information please see http://www.mh-hannover.de/zib.html.
PhD Molecular Medicine: The program aims to form a bridge between Science and the Clinic, in research as well as in teaching. We offer a wide variety of projects in the fields of Immunology, Infection, Haematology & Oncology, Biochemistry, Differentiation, Cell Biology, Genetics, and further medical departments. For more information please see http://www.mh-hannover.de/md-phd.html.

PhD Regenerative Sciences: Research and teaching concentrate on Developmental Biology, Stem Cell Biology, Biology of Ageing and Degeneration, Growth Factors and Other Regenerative Agents, Cell Therapy, Tissue Engineering including Materials and Natural Sciences, and Ethical as well as Regulatory Implications. For more information please see http://www.rebirth-hannover.de.

Your application

Applications are invited from 1st December 2010 onwards through http://www.hbrs-application.de only. Please note that any other form of application will be disregarded. Applications close on 1st April 2011. For further information on the selection process, frequently asked questions, etc please see http://www.mh-hannover.de/hbrs.html.

Research Group Leaders in Systems Biology at TU Dresden Germany

The Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), both located in Dresden, are seeking outstanding candidates for

Research Group Leaders in Systems Biology

The successful applicants could be theoretical, experimental or both, and are expected to develop an independent research program. Research at the MPI-CBG focuses on the structure and dynamic organization of cells and tissues in several model organisms (see http://www.mpi-cbg.de). This experimental research is greatly strengthened by theory, contributed through close collaborations with physicists at the MPI-PKS (http://www.mpipks-dresden.mpg.de).

In Dresden, we define systems biology broadly. In addition to more traditional activities in systems biology such as the analysis of genetic and protein signaling networks, we have a strong interest in the quantitative understanding of morphogenesis at several levels: how do molecules dynamically organize into organelles and cells, and how do interactions between cells give rise to tissues and organs? Answering these questions requires experimental and theoretical approaches, in which there is considerable strength in Dresden, but also advances in the processing and synthesis of biological data, especially images. We therefore seek applicants not just from biology bioinformatics and physics, but also from computer science and engineering.


MPI Research Group Leader positions are initially for 5 years at the EG15 level according to the TVÖD scale with the possibility of an extension. Funds are available for personnel, consumables and equipment according to the procedures at the two Institutes. Please send your CV, publication list and a short description of research accomplishments and future plans to Prof. Marino Zerial or Prof. Roderich Moessner (see addresses below), mentioning Systems Biology search, by 7 January 2011. Please also arrange for three letters of reference to be sent before the deadline. We especially encourage women to apply.

Prof. Marino Zerial
Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstr. 108, 01307 Dresden, Germany

Prof. Roderich Moessner
Max Planck Institute for the Physics of Complex Systems
Noethnitzer Str. 38, 01187 Dresden, Germany

Please send your applications to: 2010-rgl-1080@mpi-cbg.de

The Max Planck Society is committed to employ more handicapped individuals and actively seek their applications.

PhD Positions in Munich, Germany

How does our brain work? This is one of the most exciting questions of modern life sciences. Thus, neuroscience is one of the most rapidly growing fields of research. Our focus is a systemic point of view, without neglecting the molecular and cellular mechanisms. Examples of topics which are pursued within the GSN-LMU are:

• Single cells to complex systems
• System analysis to mathematical modeling
• Perception and cognition to mind and philosophy
• Biology to technical solutions

Applying for the GSN gives access to a large number of neuroscience labs in and around Munich, coming from various disciplines such as biology, medicine, psychology, engineering and even philosophy. Have a look at our homepage http://www.mcn.lmu.de/gsn and get an overview of the large spectrum of neuroscience, Munich has to offer. In your application to the GSN-LMU, you specify the working group of your choice, and we will forward your application accordingly

Postdoctoral position - DNA synthesis and repair in Umea University, Sweden

Project description:
The research is focused on ribonucleotide reductase, a key enzyme in the synthesis of the DNA building blocks, dNTPs.
One aim is to conditionally knock out the ribonucleotide reductase large subunit (R1) in differentiated mammalian cells to study:
i) The need for de novo dNTP synthesis for DNA repair in differentiated cells.
ii) The need for de novo dNTP synthesis for mitochondrial DNA replication and repair.
iii) The composition of the ribonucleotide reductase enzyme in differentiated cells.
We also want to identify ribonucleotide reductase-interacting proteins using immunoprecipitations and chromatin immunopreciptations from synchronized mammalian cell extracts.

For more details please contact Dr. Anna Lena Chabes: anna.lena.chabes@medchem.umu.se

Methods:
The studies involve standard cell and molecular biology and biochemical techniques.
*Position description: *
The position is available for the initial 2 years as a tax-exempt fellowship with a possibility of extension.

Location:
The Department of Medical Biochemistry and Biophysics consists of 15 independent groups employing around 80 people. The department is located within the Chemical Biological Centre at Umeå University and provides well- equipped common facilities and excellent platforms in a creative, inspiring and highly interactive environment.

Application details for Post-doc fellowship:
We are looking for enthusiastic candidates from all over the world who are interested in DNA synthesis and repair, and who have received or are about to receive a Ph.D. in cell/molecular biology or a related discipline. The successful candidate is expected to design and execute his or her project independently but also work in close collaboration with the other members of the team.

Applicants should submit their CV, along with the names and contact details of three reference persons, via email to Dr. Anna Lena Chabes (anna.lena.chabes@medchem.umu.se) before 31 January 2011.

Doctoral Positions in Pulmonary Research at Giessen, Germany

Doctoral Positions in Pulmonary Research in Germany
The International Graduate Program “Molecular Biology and Medicine of the Lung” (MBML) is the leading educational platform of the University of Giessen Lung Center at the Justus Liebig University in Giessen, Germany. We are now seeking highly qualified and motivated individuals for full-time doctoral studies in the laboratory of Prof. Günther. Research topics include
- molecular events underlying Usual Interstitial Pneumonia in Hermansky-Pudlak-Syndrome
- induction of ER-Stress in type two cell apoptosis and lung fibrosis via defective surfactant processing
- cell based therapies for lung fibrosis
The research is undertaken in a dynamic and exciting research environment. The University of Giessen Lung Center is one of the worlds leading pulmonary centres, and is recognised for excellence both in basic scientific research and in the clinical management of patients with lung disease.


Applications are welcomed from candidates trained in any biological discipline as well as applicants with a primary degree in human or veterinary medicine. Students will receive a monthly stipend, and depending on their qualifications and the projects selected, may be eligible to register for one of the four doctoral degrees offered, including PhD, Dr. rer. nat., Dr. biol. hum. and Dr. med. Candidates must be in possession of a Masters degree in the life sciences, or a primary degree in human or veterinary medicine. Candidates will be expected to attend an interview in Giessen prior to formal acceptance (all expenses will be covered by the University of Giessen), and are free to start their laboratory research anytime after that interview. Please consult the MBML Programme webpage http://www.uniklinikum-giessen.de/mbml for information about the Programme.


Applications, consisting of (I) a letter stating your intention to apply, (II) a current curriculum vitae, (III) a list of three potential referees, and (IV) your academic transcripts, compiled into a single PDF file of maximum size 1 MB, should be submitted to sandy.jones@innere.med.uni-giessen.de.

PhD - Helmholtz International Graduate School for Infection Research

Helmholtz International Graduate School for Infection Research
A three-year PhD program, starting in October 2011

We invite highly motivated applicants
PhD students will have the unique opportunity to undertake a PhD within an electrifying atmosphere with the focus on Infection Biology and related fields (Immunology, Microbiology, Virology, Cell Biology, Chemical Biology and Natural Product Research, Structural Biology, Bioinformatics, Systems Biology, Molecular Biology, Mammalian Genetics). As well as working on a three-year research project PhD students also attend lectures and seminars, laboratory and soft-skill courses, congresses, symposia and summer schools. The program is well supported by a network of supervisors; PhD students will finish the program as highly qualified scientists competitive for the job market. The three-year program is taught in English.
For information about the program please visit the following web site: http://www.hzigradschool.de

We expect
• A Master’s degree (or equivalent)
• Applicants who have an active interest in one or more of the above fields
• Written and spoken English skills and previous laboratory experience

Application
• Applicants are required to complete the online application form under: http://online-application.helmholtz-hzi.de

Deadline for Application
• January 15th, 2011
Since the Helmholtz Graduate School supports a gender balance, women are explicitly encouraged to apply. Further information on the Helmholtz Centre for Infection Research is to be found under: http://www.helmholtz-hzi.de. The Helmholtz International Graduate School is supported by the Helmholtz Association of German Research Centres.
The Helmholtz International Graduate School is a joint action of the institutes/universities:
• Helmholtz Centre for Infection Research, Braunschweig (HZI)
• Technical University of Braunschweig (TU-BS)
• Hannover Medical School (MHH)
• University of Veterinary Medicine Hannover (TiHo)

Two Postdoctoral Fellows, Environmental Epigenetics : Copenhagen, Denmark

Title: Two Postdoctoral Fellows, Environmental Epigenetics
Tenure: Two years
Employment Conditions:
Employment will be in accordance with the provisions of the collective agreement between the Danish Government and AC (the Danish Confederation of Professional Associations). The position will be at the level of postdoctoral fellow, however, depending on the candidate’s qualifications, s/he could attempt to apply for approval as associate professor. The gross basic salary range for Postdoctoral Fellows is DKK31,410 to DKK33,070 per month (level 6 to 8). To the basic salary a supplement could be negotiated, dependent on the candidate’s experience and qualifications. An additional 17.1% monthly contribution to pension will be paid by the employer.
Background:
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) has been established at the Faculty of Health Sciences, University of Copenhagen, to conduct research into basic metabolic functions. The center which consists of five scientific sections and a number of international research satellites was established through a grant from the Novo Nordisk Foundation. The position is in the section for Integrative Physiology headed by Juleen Zierath in the group for Environmental Epigenetics lead by Romain Barres.
Project Description:
Type 2 Diabetes is growing at pandemic rates worldwide, reflecting a synergic interaction between genetic and environmental factors. Epigenetics refers to heritable states of gene expression that are not due to changes in DNA sequence. Two major epigenetic processes, DNA methylation and histone modifications, form the molecular basis of epigenetics, principally by modulating the access of the transcription machinery to the chromatin. Previously, we showed that environmental factors such as diet participate in the etiology of T2D through epigenetic modifications in somatic tissues. The molecular mechanisms involved are yet to be identified. We are seeking two highly motivated Postdoctoral Fellows with excellent skills in molecular biology, biochemistry and cellular biology, to dissect the molecular mechanisms involved in nutrient and exercise-induced epigenetic modifications in metabolic tissues.
The project includes a range of nucleic acid related techniques (DNA and RNA extraction, miRNA cloning, bisulfite sequencing, methylcytosine capture, sequencing, pyrosequencing), cell biology techniques (tissue culture, gene expression, gene silencing, cell imaging) and excellent computing skills (knowledge of databases, design of primers and processing of sequencing results). Candidates with additional background in bioinformatics would be highly regarded.
Selection criteria:
Essential criteria
• PhD in biochemistry, molecular biology, cell biology or related science
• Expertise and experience in nucleic acids related techniques and tissue culture
• Expertise in any of the following: bisulfite sequencing, generation of miRNA libraries, sequencing, gene transfer or silencing, confocal microscopy
• Excellent computing skills related to the processing of sequencing data
• Proven track record in nucleic acid research, chromatin structure or regulation of transcription
• Excellent written and oral communication skills
• Demonstrated capacity for effective team work
Desirable criteria
• Previous background in bioinformatics
• Knowledge in mammalian physiology and metabolic diseases
Relationships:
• The post holders will report to the Leader of the Environmental Epigenetics Group (Romain Barres), the Head of the Integrative Physiology Section (Juleen Zierath) and the Managing Director of CBMR (Anne Stæhr Johansen).
• The post holders are expected to interact with staff at all levels, both internally and externally, regarding relevant research topics.
Highly motivated and ambitious candidates are encouraged to apply. Solid experience and an excellent track record gained in leading laboratories in the research field will be considered a distinct advantage. In all cases, ability to perform the job will be the primary consideration, and thus we encourage all – regardless of their personal background and status – to apply.
You can read more about the Center for Basic Metabolic Research on: http://metabol.ku.dk.
For further information, please contact Group Leader Romain Barres, email: barres@sund.ku.dk.
Your application marked “211-0004/10-3860” including a CV and list of publications must be sent as one document to NNF Center for Basic Metabolic Research before January the 3rd, 2011. Your application should be sent by e-mail to metaboljobs@sund.ku.dk.

Post-Doctoral Fellow – Biochemistry/Molecular Biology

Post-Doctoral Fellow – Biochemistry/Molecular Biology

The Centre for Drug Research and Development (CDRD) is an innovative organization that focuses on bridging the gap between academic discoveries in the health sciences and the development of new medicines to treat human diseases. With operational facilities located on the campuses of the University of British Columbia (UBC), Simon Fraser University (SFU), and the BC Cancer Agency (BCCA), CDRD has established a novel drug development platform. By working closely with Canadian academic researchers and the pharmaceutical/ biotechnology industry, CDRD provides a collaborative framework through which drug development can become sustainable, cost-effective, and advantageous to society.

Job Summary

As a Post Doctoral Fellow, Biochemistry/Molecular Biology you will be a member of a research team providing critical expertise for progression of drugs from discovery through commercialization.

Responsibilities

•Working within and across the CDRD divisions, participate on drug research and development projects requiring expertise from target validation, drug screening, organic synthesis, drug formulation and delivery, through in-vivo drug evaluation.
•Under the direction of Division Heads, you will assist CDRD Investigators from affiliated institutions with completing proof of concept packages for selected drug research projects.
•Duties may include working with investigators and other team members in developing biological assays, automating processes, performing statistical analysis, performing SNP analysis and analysis of gene and protein arrays.
•Other related duties as assigned.

Qualifications and Experience

•Recent completion or completion within the next 3 months, of a PhD in biology, biochemistry, molecular biology, or a related discipline.
•Direct experience developing either cell-based biological assays or biochemical assay’s with knowledge of gene expression analysis and fluorescent microscopy.
•Preferred candidates will be flexible, with a determination to further their skills in multiple areas.
•Willingness to contribute to and work in a team environment is required.
•A good publication record, with experience related to drug research
•Excellent oral and written communication skills

How to Apply

Please forward your application, in PDF format, to careers@cdrd.ca. Please ensure your submission is in PDF format (ideally in one document) indicating your surname in the filename. For example: smithjohn-cover-resume.pdf.

We thank all interested applicants for their interest, however, only those applicants short-listed will be contacted for an interview.

Application Closing Date: Until Filled

PostDoc in Stem Cell Biology

The Helmholtz-Institute for Biomedical Engineering, Department for Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School
is offering a position for a Scientist (Postdoc) starting at February 1st 2011.
The work will be embedded in the project “StemCellFactory” with the aim of automated isolation, expansion and differentiation of induced pluripotent stem cells (iPS cells).
Our group addresses molecular characteristics of human adult stem cells. A focus is on mesenchymal stem cells (MSC) which represent precursors for bone, cartilage and adipose tissue. We analyze the impact of biomaterials, surface structure, 3D-scaffolds and culture media. Furthermore, we determine effects of cellular aging (with respect to long-term culture as well as between young and elderly donors). The molecular sequels are analyzed by gene expression profiling and epigenetic analysis of DNA-methylation. Specific aims of our subproject are optimization of reliable cell culture processes for automation of various processes (initial isolation of fibroblasts and MSC, molecular characterization, reprogramming and cloning).
Various methods are applied including isolation and characterization of primary cell preparations, iPS-technology, flow cytometry, immunofluorescence and confocal microscopy, qRT-PCR, blotting techniques, microarray platforms and sequencing (for mRNA, miRNA and DNA-methylation profiles) as well as functional assays.
We are looking for a motivated and ambitious scientist with a strong background in stem cell biology. Experience in the work with iPS would be appreciated.
We offer a highly interactive and well equipped environment in an excellent team of partners, a broad spectrum of methods and a highly relevant topic. Initial employment will be for two and a half years (TV-L E13) with the possibility for extension.
The University RWTH Aachen supports women in science and especially encourages them to apply. Handicapped applicants with equal qualifications will be preferred.
Your application should include a cover letter, CV and copies of the most important certificates. It can be send by mail or by e-mail. We are looking forward to your application!
Prof. Dr. Dr. Wolfgang Wagner
Helmholtz-Institute for Biomedical Engineering
- Stem Cell Biology and Cellular Engineering –
Pauwelsstrasse 20
52074 Aachen
wwagner@ukaachen.de